New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism

doi:10.3748/wjg.v26.i40.6224

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2020; 26(40): 6224-6240
Published online Oct 28, 2020. doi: 10.3748/wjg.v26.i40.6224

New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism

Xian-Wan Jiang, Ya-Ting Li, Jian-Zhong Ye, Long-Xian Lv, Li-Ya Yang, Xiao-Yuan Bian, Wen-Rui Wu, Jing-Jing Wu, Ding Shi, Qing Wang, Dai-Qiong Fang, Kai-Cen Wang, Qiang-Qiang Wang, Yan-Meng Lu, Jiao-Jiao Xie, Lan-Juan Li, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China

Author contributions: Jiang XW, Lv LX and Li LJ conceptualized the study; Li YT, Ye JZ and Wang KC performed data curation; Wu JJ and Wang Q completed the formal analysis; Li LJ provided funding acquisition; Wang KC, Yang LY and Lu YM completed the experiments; Jiang XW, Li YT, Ye JZ, Bian XY and Wu WR supplied the methodology; Li LJ administered the project; Ye JZ and Fang DQ provided software support; Lv LX supervised the study; Yang LY and Xie JJ finished the validation; Shi D visualized the data; Jiang XW and Wang QQ wrote the original draft; Jiang XW and Li LJ reviewed and edited the manuscript.

Supported by National Natural Science Foundation of China, No. 81330011, No. 81790631, No. 81570512, and No. 81790633; Science Fund for Creative Research Groups of the National Natural Science Foundation of China, No. 81121002; and National Key Research and Development Program of China, No. 2018YFC2000500.

Institutional review board statement: This study was reviewed and approved by the review board of The First Affiliated Hospital, College of Medicine, Zhejiang University.

Institutional animal care and use committee statement: All experimental procedures were approved by the Animal Care and Use Committee of The First Affiliated Hospital, College of Medicine, Zhejiang University.

Conflict-of-interest statement: The authors have no conflicts of interest related to this study to disclose.

Data sharing statement: No additional data are available.

ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Corresponding author: Lan-Juan Li, PhD, Academic Research, Doctor, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn

Received: June 23, 2020
Peer-review started: June 23, 2020
First decision: July 28, 2020
Revised: August 8, 2020
Accepted: September 11, 2020
Article in press: September 11, 2020
Published online: October 28, 2020

Core Tip

Core Tip: Gut microbiota dysbiosis plays an important role in the progression of ethanol-induced liver injury, but an effective microbe-based therapy is lacking. Our study screened an ethanol-resistant strain of Pediococcus pentosaceus (P. pentosaceus) as a potential probiotic. Preliminary results indicated that the new strain of P. pentosaceus modulated the composition of the gut microbiota and short-chain fatty acid metabolism to protect against ethanol-induced liver injury in a mouse model.