Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2020; 26(4): 416-423
Published online Jan 28, 2020. doi: 10.3748/wjg.v26.i4.416
Regional variation of pediatric inflammatory bowel disease in Saudi Arabia: Results from a multicenter study
Mohammad I El Mouzan, Mohammed H AlEdreesi, Mohammed Y Hasosah, Abdulrahman A Al-Hussaini, Ahmad A Al Sarkhy, Asaad A Assiri
Mohammad I El Mouzan, Ahmad A Al Sarkhy, Asaad A Assiri, Department of Pediatrics, Gastroenterology Unit, King Saud University, Riyadh11461, Saudi Arabia
Mohammed H AlEdreesi, Specialty Pediatrics Division, Pediatric Gastroenterology, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia
Mohammed Y Hasosah, Department of Pediatrics, Gastroenterology Unit, King Saud bin Abdulaziz University for Health Sciences, Jeddah 21423, Saudi Arabia
Abdulrahman A Al-Hussaini, Children Hospital, Gastroenterology Division, King Fahad Medical City, Riyadh 11525, Saudi Arabia
Asaad A Assiri, Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research Chair, Gastroenterology Unit, King Saud University, Riyadh 11461, Saudi Arabia
Author contributions: El Mouzan MI designed the study and drafted the manuscript, AlEdreesi MH, Hasosah MY, Al-Hussaini AA, Al Sarkhy AA, and Assiri AA contributed equally to data collection and critical review of the manuscript. All authors reviewed the final manuscript.
Supported by the Deanship for Scientific Research, King Saud University, Riyadh, Kingdom of Saudi Arabia, No. RGP-1436-007.
Institutional review board statement: This manuscript is a portion of the project entitled “the characteristics of inflammatory bowel disease in Saudi children” approved by the IRB of the College of Medicine, King Saud University (No: 10/2647/IRB in 29/6/2010).
Informed consent statement: Parents and/or children gave consent and/or assent to participate in the study before enrollment.
Conflict-of-interest statement: All authors declare no conflict of interest related to this study
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mohammad I El Mouzan, MD, Professor and Consultant Pediatrician, Department of Pediatrics, Gastroenterology Unit, College of Medicine, King Saud University, King Abdullah Road, PO BOX 2925, Riyadh 11461, Saudi Arabia. drmouzan@gmail.com
Received: September 9, 2019
Peer-review started: September 5, 2019
First decision: September 19, 2019
Revised: December 31, 2019
Accepted: January 8, 2020
Article in press: January 8, 2020
Published online: January 28, 2020
Core Tip

Core tip: This article reports regional variations of Crohn’s disease and ulcerative colitis in the Central region, Western region, and the Eastern region of the Kingdom of Saudi Arabia. Although incidence trend was increasing in all regions, children from the Eastern region presented with a significantly more severe Crohn’s disease than those from the Central region and Western region. Regional analysis in other countries may reveal significant variations indicating the need for prospective studies to identify the causes of such variations.