Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2020; 26(37): 5629-5645
Published online Oct 7, 2020. doi: 10.3748/wjg.v26.i37.5629
Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl4-induced liver injury in mice
Xiao Meng, Guo-Yi Tang, Pin-He Liu, Chan-Juan Zhao, Qing Liu, Hua-Bin Li
Xiao Meng, Guo-Yi Tang, Pin-He Liu, Qing Liu, Hua-Bin Li, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Chan-Juan Zhao, Department of Bio-statistics, School of Public Health, Hainan Medical University, Haikou 571199, Hainan Province, China
Author contributions: Meng X and Li HB contributed to the conception and design of the study; Meng X, Tang GY, Liu PH, and Liu Q performed the experiments and acquired data; Meng X and Liu PH drafted the article; Tang GY, Zhao CJ, and Liu Q made critical revisions; all authors approved the final version of the article.
Institutional animal care and use committee statement: All experimental procedures were performed based on the approval of Animal Ethics Committee of School of Public Health, Sun Yat-Sen University (No. 2017-011).
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xiao Meng, PhD, Lecturer, Department of Nutrition, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou 510080, Guangdong Province, China.
Received: June 12, 2020
Peer-review started: June 12, 2020
First decision: July 25, 2020
Revised: July 28, 2020
Accepted: September 9, 2020
Article in press: September 9, 2020
Published online: October 7, 2020
Core Tip

Core Tip: Many natural products confer health benefits against diverse diseases through their antioxidant activities. In this study, ten medicinal herbs were selected for an evaluation and comparison of their effects on carbon tetrachloride (CCl4)-induced oxidative liver injury. Sanguisorba officinalis (S. officinalis) L. exhibited the strongest hepatoprotective effect, and the strongest in vitro activities were also found for S. officinalis L. Our results provided valuable information for the selection of more efficient herbs to protect against CCl4-induced liver injury and to support the direct application of herbs or the development of novel therapies for the management of oxidative stress-related diseases.