Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2020; 26(35): 5302-5313
Published online Sep 21, 2020. doi: 10.3748/wjg.v26.i35.5302
Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years
Aydin Dadfar, Tom-Harald Edna
Aydin Dadfar, Tom-Harald Edna, Department of Surgery, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger 7600, Norway
Tom-Harald Edna, Institute of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7491, Norway
Author contributions: Dadfar A made substantial contributions to the conception and design of the study, acquisition, analysis, and interpretation of data, and drafting the article; Edna TH made substantial contributions to the conception and design of the study, acquisition, analysis, and interpretation of data, and drafting the article; all authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Levanger Hospital Institutional Review Board Committee on Human Rights Related to Research Involving Human Subjects (2018/2760 – 33974/2018).
Informed consent statement: Not necessary according to the Regional Committee for Medical and Health Research Ethics (REC), Helse Midt (2018/1510).
Conflict-of-interest statement: The authors declare the absence of conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Aydin Dadfar, MD, Surgeon, Department of Surgery, Levanger Hospital, Nord-Trøndelag Hospital Trust, Kirkegata 2, Levanger 7600, Norway. aydindadfar@gmail.com
Received: March 24, 2020
Peer-review started: March 24, 2020
First decision: April 25, 2020
Revised: June 23, 2020
Accepted: August 29, 2020
Article in press: August 29, 2020
Published online: September 21, 2020
Processing time: 176 Days and 15.6 Hours
Core Tip

Core Tip: We sought to review the epidemiology of perforated peptic ulcer in a stable population at a primary hospital over a period of 40 years. The incidence rate has declined in recent decades for both sexes, though median age and comorbidity have both increased. Complications occurred more frequently and were more serious in recent decades, in older patients, in patients with comorbidities, and in patients with higher American Society of Anaesthesiologists (ASA) scores. Both short- and long-term survival were associated with ASA score, without significant variation between the decades.