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World J Gastroenterol. Sep 7, 2020; 26(33): 4919-4932
Published online Sep 7, 2020. doi: 10.3748/wjg.v26.i33.4919
Exploring the food-gut axis in immunotherapy response of cancer patients
Edda Russo, Giulia Nannini, Monica Dinu, Giuditta Pagliai, Francesco Sofi, Amedeo Amedei
Edda Russo, Giulia Nannini, Monica Dinu, Giuditta Pagliai, Francesco Sofi, Amedeo Amedei, Department of Clinical and Experimental Medicine, University of Florence, Florence 50134, Italy
Francesco Sofi, Unit of Clinical Nutrition, Careggi University Hospital, Florence 50139, Italy
Amedeo Amedei, SOD of Interdisciplinary Internal Medicine, Azienda Ospedaliera Universitaria Careggi, Florence 50134, Italy
Author contributions: Russo E and Amedei A contributed to conceptualization; Russo E, Nannini G, Amedei A and Sofi F contributed to investigation; Russo E, Dinu M, Pagliai G and Nannini G contributed to writing; Russo E, Sofi F and Amedei A contributed to review, supervision and funding acquisition; Russo E and Nannini G contributed to editing; Russo E, Dinu M, and Nannini G contributed to visualization.
Supported by the Italian Ministry of University and Research, the Foundation “Ente Cassa di Risparmio di Firenze” FCR 2017; Italian Ministry of Health (Ricerca Finalizzata 2016), No. GR-2016-02361162.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Amedeo Amedei, MSc, Associate Professor, Department of Clinical and Experimental Medicine, University of Florence, Viale Pieraccini 6, Florence 50134, Italy. amedeo.amedei@unifi.it
Received: May 29, 2020
Peer-review started: May 29, 2020
First decision: June 12, 2020
Revised: June 16, 2020
Accepted: August 22, 2020
Article in press: August 22, 2020
Published online: September 7, 2020
Processing time: 97 Days and 20.6 Hours
Core Tip

Core tip: Diet is one of the major gut microbiota determinants; ongoing studies are examining the interaction between diet, gut microbiota and immunity. Diet-related factors and supplements appear to have effects on a patient’s responsivity to anti-cancer immunotherapy, via modulation of intestinal microbiota.