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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2020; 26(33): 4889-4899
Published online Sep 7, 2020. doi: 10.3748/wjg.v26.i33.4889
Published online Sep 7, 2020. doi: 10.3748/wjg.v26.i33.4889
Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation
Ronald Neil Kostoff, School of Public Policy, Georgia Institute of Technology, Gainesville, VA 20155, United States
Michael Brandon Briggs, Independent Consultant, Roscommon, MI 48653, United States
Darla Roye Shores, The Hopkins Resource for Intestinal Vitality and Enhancement, the Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
Author contributions: Kostoff RN contributed to this paper with conception, data analysis, and writing the manuscript; Briggs MB participated in data analysis, results validation, and figure and table development; Shores DR contributed to query development, background development, prioritization of results, and editing; all the authors approved the final version of the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ronald Neil Kostoff, PhD, Research Affiliate, School of Public Policy, Georgia Institute of Technology, 13500 Tallyrand Way, Gainesville, VA 20155, United States. ronald.kostoff@pubpolicy.gatech.edu
Received: May 5, 2020
Peer-review started: May 5, 2020
First decision: May 15, 2020
Revised: May 21, 2020
Accepted: August 27, 2020
Article in press: August 27, 2020
Published online: September 7, 2020
Peer-review started: May 5, 2020
First decision: May 15, 2020
Revised: May 21, 2020
Accepted: August 27, 2020
Article in press: August 27, 2020
Published online: September 7, 2020
Core Tip
Core tip: A text-mining approach was used to identify treatments from non-inflammatory bowel disease (IBD) diseases that could be extrapolated to treat IBD. Sixty-four treatment concepts were identified in different phases of development, ranging from laboratory research to clinical application. Many more were possible with a longer and well-resourced study. Ten of the non-IBD concepts that were excluded from being classified as discovery would have been classified as discovery if the study had been conducted in 2016. Thus, this approach has the capability to identify/predict many new areas of research for treating IBD.