Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2020; 26(32): 4857-4865
Published online Aug 28, 2020. doi: 10.3748/wjg.v26.i32.4857
Published online Aug 28, 2020. doi: 10.3748/wjg.v26.i32.4857
Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure
Su Lin, Xiao-Zhong Wang, Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou 350000, Fujian Province, China
Yan-Yan Yan, Yin-Lian Wu, Ming-Fang Wang, Yue-Yong Zhu, Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, Fujian Province, China
Yan-Yan Yan, Clinical Liver Center, The 180th Hospital of People’s Liberation Army, Quanzhou Fujian Province, 362100, China
Author contributions: Lin S designed the study; Wang MF and Yan YY collected and analyzed the data; Lin S, Yan YY and Wu YL drafted the manuscript; Zhu YY and Wang XZ contributed to critical comments of the manuscript; all authors approved the final version of the manuscript prior to submission.
Supported by the Chinese National Science and Technology Projects , No. 2017ZX10202201 .
Institutional review board statement: The study was approved by the Ethics Committee of the First Affiliated Hospital of Fujian Medical University.
Informed consent statement: All patients hospitalized in the First Affiliated Hospital of Fujian Medical University sign a written consent for anonymous use of digital data for scientific research. We are not able to present each document of the included 386 cases. An example of the consent is shown below.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: Not available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Zhong Wang, MD, PhD, Chief Doctor, Department of Gastroenterology, Union Hospital of Fujian Medical University, No. 29 Shengmiao Road, Gulou, Fuzhou 350000, Fujian Province, China. drwangxz@163.com
Received: May 23, 2020
Peer-review started: May 23, 2020
First decision: June 12, 2020
Revised: June 18, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 28, 2020
Peer-review started: May 23, 2020
First decision: June 12, 2020
Revised: June 18, 2020
Accepted: July 30, 2020
Article in press: July 30, 2020
Published online: August 28, 2020
Core Tip
Core tip: This is a retrospective study evaluating the diagnostic value of widely used biomarkers for infection, including procalcitonin (PCT), white blood cells, proportion of neutrophils (N%), and C-reactive protein (CRP) for bacterial infection in ACLF. The results showed that all four parameters did not perform well in ACLF, with no significant difference found among them. A novel scoring system was developed comprised of N%, PCT and CRP which demonstrated higher accuracy for bacterial infection in ACLF than the indicators used alone. Further validation of this scoring system is required in prospective studies.