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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2020; 26(3): 307-323
Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.307
Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.307
Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer
Yan-Ke Li, Qian Xu, Li-Ping Sun, Yue-Hua Gong, Jing-Jing Jing, Cheng-Zhong Xing, Yuan Yuan, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, Key Laboratory of Cancer Etiology and Prevention of Liaoning Education Department, Key Laboratory of GI Cancer Etiology and Prevention of Liaoning Province, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Yan-Ke Li, Cheng-Zhong Xing, Department of Anorectal Surgery, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Yuan Y designed the study and revised the manuscript; Xing CZ recruited the patients; Sun LP collected the data; Xu Q, Gong YH, and Jing JJ performed the experiments; Li YK analyzed the data and drafted the manuscript.
Supported by the National Key R&D Program of China , No. 2018YFC1311600 .
Institutional review board statement: The study was approved by the Ethics Committee of the First Hospital of China Medical University.
Informed consent statement: All subjects provided written informed consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data is available.
STROBE statement: The guidelines of STROBE Statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yuan Yuan, MD, PhD, Professor, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, No. 155, Nanjingbei Street, Heping District, Shenyang 110001, Liaoning Province, China. yuanyuan@cmu.edu.cn
Received: October 12, 2019
Peer-review started: October 12, 2019
First decision: November 27, 2019
Revised: December 26, 2019
Accepted: January 1, 2020
Article in press: January 1, 2020
Published online: January 21, 2020
Peer-review started: October 12, 2019
First decision: November 27, 2019
Revised: December 26, 2019
Accepted: January 1, 2020
Article in press: January 1, 2020
Published online: January 21, 2020
Core Tip
Core tip: We conducted a two-stage case-control study to explore the association of all tag-single nucleotide polymorphisms (SNPs) in eight nucleotide excision repair pathway genes with colorectal cancer (CRC) risk and prognosis in a northern Chinese population, including a discovery and validation stage. We newly found that two SNPs (XPA rs10817938 and XPC rs2607775) contributed to an increased CRC risk in overall and stratification analyses. Another two SNPs (ERCC2 rs1052555 and ERCC5 rs2228959) were also first reported to be associated with a poor CRC prognosis.