Published online Jul 14, 2020. doi: 10.3748/wjg.v26.i26.3712
Peer-review started: March 28, 2020
First decision: April 18, 2020
Revised: April 23, 2020
Accepted: July 1, 2020
Article in press: July 1, 2020
Published online: July 14, 2020
Core tip: Functional gastrointestinal symptoms, in the absence of inflammation, affect around one-third of inflammatory bowel disease (IBD) patients in remission, causing significant psychological distress and impairment of quality of life. As IBD therapies continue to advance, functional gastrointestinal symptoms, as a consequence of previous inflammation, are set to become a bigger problem. Here, we review the current evidence base, highlight a recently proposed diagnostic algorithm, and discuss empirical treatment guidance for functional gastrointestinal symptoms in quiescent IBD. We also discuss future considerations and areas of unmet need to stimulate further research.