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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2020; 26(24): 3432-3446
Published online Jun 28, 2020. doi: 10.3748/wjg.v26.i24.3432
Published online Jun 28, 2020. doi: 10.3748/wjg.v26.i24.3432
Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology
Xiao Meng, Guo-Yi Tang, Cai-Ning Zhao, Qing Liu, Xiao-Yu Xu, Shi-Yu Cao, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: Meng X, Tang GY, and Zhao CN contributed to the conception and design of the study; Meng X, Tang GY, Zhao CN, Liu Q, Xu XY, and Cao SY performed the experiments and acquired data; Meng X drafted the manuscript; Tang GY, Zhao CN, and Liu Q made critical revisions; all authors approved the final version of the manuscript.
Institutional animal care and use committee statement: All experimental procedures were performed based on the approval of Animal Ethics Committee of School of Public Health, Sun Yat-Sen University (No. 2017-011).
Conflict-of-interest statement: The authors declared that they have no conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao Meng, PhD, Lecturer, Department of Nutrition, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou 510080, Guangdong Province, China. mengx7@mail2.sysu.edu.cn
Received: March 4, 2020
Peer-review started: March 4, 2020
First decision: April 12, 2020
Revised: April 24, 2020
Accepted: May 30, 2020
Article in press: May 30, 2020
Published online: June 28, 2020
Processing time: 115 Days and 23.1 Hours
Peer-review started: March 4, 2020
First decision: April 12, 2020
Revised: April 24, 2020
Accepted: May 30, 2020
Article in press: May 30, 2020
Published online: June 28, 2020
Processing time: 115 Days and 23.1 Hours
Core Tip
Core tip: Although some parts of Hovenia dulcis (H. dulcis) provide health impacts, the effects and mechanisms of H. dulcis seeds on alcoholic liver disease (ALD) have not been fully elucidated. In this study, we found that H. dulcis seeds possessed strong antioxidant activity and contained considerable phenols and flavonoids. H. dulcis seeds attenuated ALD and improved hepatic antioxidant capacity. Furthermore, results of network pharmacology analyses indicated that kaempferol, stigmasterol, and naringenin were the main bioactive compounds in H. dulcis seeds and that modulating oxidative stress, inflammation, gut-derived products, and apoptosis were involved in the mechanisms underlying the protective effects of H. dulcis seeds on ALD.