Meta-Analysis
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2020; 26(23): 3304-3317
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3304
Value of intravoxel incoherent motion in detecting and staging liver fibrosis: A meta-analysis
Zheng Ye, Yi Wei, Jie Chen, Shan Yao, Bin Song
Zheng Ye, Yi Wei, Jie Chen, Shan Yao, West China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Bin Song, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Ye Z contributed to the conception and design of the study, carried out acquisition, analysis, and interpretation of data, and drafted the article; Wei Y and Chen J interpreted the data and revised the article; Yao S carried out acquisition, analysis, and interpretation of data; Song B contributed to the conception and design of the study and final approval; All authors approved the final version of the article.
Supported by the National Nature Science Foundation of China, No. 81771797 and No. 81971571; and the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, No. ZYJC18008.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bin Song, PhD, Chief Doctor, Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. songb_radiology@163.com
Received: December 30, 2019
Peer-review started: December 30, 2019
First decision: February 18, 2020
Revised: March 26, 2020
Accepted: May 29, 2020
Article in press: May 29, 2020
Published online: June 21, 2020
Processing time: 173 Days and 23.1 Hours
Core Tip

Core tip: Intravoxel incoherent motion (IVIM) can separately evaluate the change of true molecular diffusion and perfusion-related diffusion caused by liver fibrosis (LF). This is the first meta-analysis to investigate the performance of IVIM for LF detection and staging with comprehensive diagnostic estimates. The results showed that IVIM is a valuable tool in noninvasively detecting and staging LF. However, field strength, the number and distribution of b-values, as well as the triggering methods affect the diagnostic accuracy. There is still a need to establish an optimized and standardized IVIM protocol for LF diagnosis in clinical practice.