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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2020; 26(23): 3249-3259
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3249
Published online Jun 21, 2020. doi: 10.3748/wjg.v26.i23.3249
Medications in type-2 diabetics and their association with liver fibrosis
Mohamed Tausif Siddiqui, Hina Amin, Wael Al-Yaman, Amandeep Singh, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH 44195, United States
Rajat Garg, Pravallika Chadalavada, Department of Hospital Medicine, Cleveland Clinic, OH 44195, United States
Rocio Lopez, Department of Quantitative Health Sciences, Cleveland Clinic, OH 44195, United States
Author contributions: Siddiqui MT, Amin H, Al-Yaman W and Singh A were involved in conceptualization, data curation, and project administration; Siddiqui MT, Amin H, Al-Yaman W, Singh A, Chadalvada P and Garg R were involved in writing; Lopez R performed the statistical analysis; all authors were involved in interpretation of the results, reviewing and editing of the draft.
Institutional review board statement: The study was reviewed and approved for publication by our Institutional Reviewer.
Informed consent statement: This was a retrospective study which involved the chart review. Requirement for individual patient consent was waived by the IRB.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at singha4@ccf.org.
STROBE statement: The guidelines of the STROBE Statement have been adopted and implemented.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Amandeep Singh, MD, Attending Doctor, Staff Physician, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave Suite-A5, Cleveland, OH 44195, United States. singha4@ccf.org
Received: January 31, 2020
Peer-review started: January 31, 2020
First decision: February 27, 2020
Revised: June 6, 2020
Accepted: June 10, 2020
Article in press: June 10, 2020
Published online: June 21, 2020
Peer-review started: January 31, 2020
First decision: February 27, 2020
Revised: June 6, 2020
Accepted: June 10, 2020
Article in press: June 10, 2020
Published online: June 21, 2020
Core Tip
Core tip: Prevalence of non-alcoholic fatty liver disease is increasing worldwide. Certain medications such as HMG-CoA reductase inhibitors (statins) and Angiotensin converting enzyme inhibitors have been shown to be associated with reduction in advanced fibrosis in patients with viral hepatitis. Patients with T2D are at a higher risk of developing advanced fibrosis. Given that these patients require lifelong medications to treat type 2 diabetes, we sought to analyze their association with biopsy proven liver fibrosis. We hope that our findings will help researchers in the future explore and design prospective studies to further enhance our understanding of this association.