Prospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2020; 26(20): 2657-2668
Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2657
Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer
Davide Ippolito, Silvia Girolama Drago, Anna Pecorelli, Cesare Maino, Giulia Querques, Ilaria Mariani, Cammillo Talei Franzesi, Sandro Sironi
Davide Ippolito, Silvia Girolama Drago, Anna Pecorelli, Cesare Maino, Giulia Querques, Ilaria Mariani, Cammillo Talei Franzesi, Department of Diagnostic Radiology, H. S. Gerardo Monza, San Gerardo Hospital, University of Milano-Bicocca, Monza 20900, Italy
Sandro Sironi, Department of Diagnostic Radiology, Papa Giovanni XXIII Hospital, University of Milano-Bicocca, Bergamo 20110, Italy
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Institutional review board statement: The study was ethically approved by the San Gerardo Hospital Ethics Committee.
Clinical trial registration statement: This study is registered at “San Gerardo Hospital” trial registry. The registration identification number is EP 15673/19.
Informed consent statement: Informed consent was obtained from all patients.
Conflict-of-interest statement: All the authors are aware of the content of the manuscript and have no conflict of interest.
Data sharing statement: There are no additional data available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Davide Ippolito, MD, Adjunct Professor, Staff Physician, Department of Diagnostic Radiology, H. S. Gerardo Monza, San Gerardo Hospital, University of Milano-Bicocca, Via Pergolesi 33, Monza 20900, Italy. davide.atena@tiscalinet.it
Received: January 14, 2020
Peer-review started: January 14, 2020
First decision: February 29, 2020
Revised: April 30, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: May 28, 2020
Processing time: 134 Days and 21.8 Hours
Core Tip

Core tip: The management of rectal cancer has changed in the past years. The possibility to achieve a complete response after chemo-radiotherapy and the results of non-surgical management of the disease (“watch and wait” approach) highlighted the need to obtain an accurate assessment of complete response. In this setting, dynamic-contrast-enhanced magnetic resonance imaging, which provides valuable information about the degree of angiogenesis, is considered a promising functional tool. This study aimed to assess dynamic-contrast enhanced-parameters differences between the tumor tissue and the healthy rectal wall, both before and after chemo-radiotherapy, and to find a possible correlation with pathological findings and TNM stage.