Clinical and Translational Research
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2020; 26(20): 2618-2631
Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2618
Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients
Chiko Sato, Kingo Hirasawa, Yoko Tateishi, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Masafumi Nishio, Ryosuke Kobayashi, Makomo Makazu, Hiroaki Kaneko, Yoshiaki Inayama, Shin Maeda
Chiko Sato, Kingo Hirasawa, Yuichiro Ozeki, Atsushi Sawada, Ryosuke Ikeda, Takehide Fukuchi, Masafumi Nishio, Ryosuke Kobayashi, Makomo Makazu, Endoscopy Division, Yokohama City University Medical Center, Yokohama 232-0024, Japan
Yoko Tateishi, Department of Histopathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
Hiroaki Kaneko, Shin Maeda, Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
Yoshiaki Inayama, Division of Pathological Diagnosis, Yokohama City University Medical Center, Yokohama 232-0024, Japan
Author contributions: Sato C and Hirasawa K contributed to conception and design. Sato C, Hirasawa K, Ikeda R, Sawada A, Nishio M, Fukuchi T, Kobayashi R, Makazu M, and Kaneko H contributed to acquisition of data. Hirasawa K and Sato C contributed to the analysis and interpretation of data. Tateishi Y and Inayama Y contributed to histopathological evaluation. Hirasawa K contributed to the drafting of the article. Hirasawa K and Maeda S contributed to the critical revisions of the article. Hirasawa K and Maeda S approved the final version of the article. All authors contributed to experimental design, data collection, and data analysis. All authors read and approved the final manuscript.
Institutional review board statement: The study protocol was approved by the Ethics Committee of Yokohama City University Medical Center Hospital (Approval number: D1602024).
Informed consent statement: Patients were not required to provide informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflicts of interest related to the manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kingo Hirasawa, MD, PhD, Associate Professor, Chief Doctor, Endoscopy Division, Yokohama Medical University Center Hospital, 4-57, Urafune-cho, Minami-ku, Yokohama 232-0024, Japan. kingo-h@urahp.yokohama-cu.ac.jp
Received: January 28, 2020
Peer-review started: January 28, 2020
First decision: February 27, 2020
Revised: March 25, 2020
Accepted: May 14, 2020
Article in press: May 14, 2020
Published online: May 28, 2020
Processing time: 111 Days and 3.2 Hours
Core Tip

Core tip: Chronic Helicobacter pylori (H. pylori) infection is a major risk factor for gastric cancer. Historically, gastric cancers in Japan were related to H. pylori infection, and the frequency of H. pylori uninfected gastric cancer (HpUIGC) was very rare. However, the rarity of gastric cancer in H. pylori negative patients may be partly owing to underreporting, and the mechanisms behind the development and progression of this type of gastric cancer must be elucidated. This study elucidated the clinicopathological features of H. pylori uninfected gastric cancer from 30 gastric cancer patients. Differentiated-type gastric cancers without submucosal invasion were most prominent.