Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2020; 26(20): 2498-2513
Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2498
Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer: Focus on short and long-term outcomes
Ilenia Bartolini, Matteo Risaliti, Maria Novella Ringressi, Filippo Melli, Giulia Nannini, Amedeo Amedei, Paolo Muiesan, Antonio Taddei
Ilenia Bartolini, Matteo Risaliti, Maria Novella Ringressi, Filippo Melli, Giulia Nannini, Amedeo Amedei, Paolo Muiesan, Antonio Taddei, Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy
Author contributions: Bartolini I, Risaliti M and Taddei A conceptualized the manuscript; Bartolini I and Risaliti M wrote original draft preparation; all the authors wrote, reviewed and edited the manuscript; Amedei A, Taddei A and Muiesan P supervised.
Supported by University of Florence, No. ex60%2018.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Amedeo Amedei, MSc, Professor, Biologist, Department of Experimental and Clinical Medicine, University of Florence, Viale Pieraccini 6, Florence 50134, Italy. amedeo.amedei@unifi.it
Received: December 30, 2020
Peer-review started: December 30, 2019
First decision: January 19, 2020
Revised: March 27, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: May 28, 2020
Processing time: 150 Days and 3.2 Hours
Core Tip

Core tip: Microbiome and immunity sciences are fields in rapid evolution gaining growing attention. The gut microbiota-immunity interplay seems to have a very important role in all the different phases of colorectal cancer process from oncogenesis to treatment and prognosis. However, many aspects have been studied only in experimental models and many theories must still be proved in humans. Providing the actual state of art of this interplay on the different steps involved in colorectal cancer, new multidisciplinary studies in humans according to this perspective may be drafted with the purpose of widening the possibilities of treatment against this frequently diagnosed pathology.