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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2020; 26(20): 2472-2478
Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2472
Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2472
Can adiponectin have an additional effect on the regulation of food intake by inducing gastric motor changes?
Eglantina Idrizaj, Rachele Garella, Roberta Squecco, Maria Caterina Baccari, Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy
Author contributions: Baccari MC conceived the paper; Idrizaj E, Garella R, Squecco R and Baccari MC contributed to writing the paper; Idrizaj E, Garella R, Squecco R and Baccari MC critically revised the manuscript and approved the final version.
Supported by the CRF Foundation , No. 2017.0777 .
Conflict-of-interest statement: No conflicts of interest, financial or otherwise, are declared by the authors.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Maria Caterina Baccari, PhD, Associate Professor, Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Viale G.B. Morgagni 63, Florence 50134, Italy. mcaterina.baccari@unifi.it
Received: December 23, 2019
Peer-review started: December 23, 2019
First decision: March 27, 2020
Revised: April 13, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: May 28, 2020
Peer-review started: December 23, 2019
First decision: March 27, 2020
Revised: April 13, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: May 28, 2020
Core Tip
Core tip: Central structures involved in the regulation of food intake receive and integrate signals from peripheral organs, including white adipose tissue. This paper summarizes the main findings on the influence of adiponectin, a pleiotropic hormone secreted by adipocytes, on food intake. In addition to its central actions, adiponectin has been recently reported to cause gastric motor changes known to be peripheral signals implicated in the hunger-satiety cycle. In this light, we discuss the potential role of adiponectin as a peripheral signal in the signaling network underlying hunger and satiety.