Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2020; 26(2): 109-133
Published online Jan 14, 2020. doi: 10.3748/wjg.v26.i2.109
Published online Jan 14, 2020. doi: 10.3748/wjg.v26.i2.109
Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C
Sudeep Tanwar, Freya Rhodes, Ankur Srivastava, Paul M Trembling, William M Rosenberg, UCL Institute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Campus, Hampstead, London NW3 2PF United Kingdom
Sudeep Tanwar, Department of Gastroenterology, Whipps Cross University Hospital, Barts Health NHS Trust, Leytonstone, London E11 1NR, United Kingdom
Author contributions: All authors equally contributed to this paper with conception, literature review, analysis, drafting, critical revision, editing and approval of the final version.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sudeep Tanwar, MBBS, MRCP(UK), FRCP, FEBGH, PhD, Consultant Gastroenterologist and Hepatologist, Department of Gastroenterology, Whipps Cross University Hospital, Barts Health NHS Trust, Leytonstone, London E11 1NR, United Kingdom. sudeep.tanwar@nhs.net
Received: September 26, 2019
Peer-review started: September 26, 2019
First decision: November 4, 2019
Revised: December 17, 2019
Accepted: January 1, 2020
Article in press: January 1, 2020
Published online: January 14, 2020
Processing time: 108 Days and 15.1 Hours
Peer-review started: September 26, 2019
First decision: November 4, 2019
Revised: December 17, 2019
Accepted: January 1, 2020
Article in press: January 1, 2020
Published online: January 14, 2020
Processing time: 108 Days and 15.1 Hours
Core Tip
Core tip: Only by having a comprehensive understanding of the pathophysiology of chronic liver disease can appropriate and meaningful diagnostic targets for research studies be identified. For clinicians who are not engaged in laboratory research this also requires a revision of basic anatomy, physiology and immunology. In this review article we have attempted to go “back to basics” to enable liver specific pathophysiology to be contextualised thereby allowing clinicians who are not engaged in laboratory practice to engage in translational research.