Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2020; 26(16): 1938-1949
Published online Apr 28, 2020. doi: 10.3748/wjg.v26.i16.1938
Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation
Elodie Fallet, Michel Rayar, Amandine Landrieux, Christophe Camus, Pauline Houssel-Debry, Caroline Jezequel, Ludivine Legros, Thomas Uguen, Martine Ropert-Bouchet, Karim Boudjema, Dominique Guyader, Edouard Bardou-Jacquet
Elodie Fallet, Amandine Landrieux, Pauline Houssel-Debry, Caroline Jezequel, Ludivine Legros, Thomas Uguen, Dominique Guyader, Edouard Bardou-Jacquet, Service des Maladies du Foie, CHU Rennes, University Rennes, Rennes 35033, France
Michel Rayar, Pauline Houssel-Debry, Karim Boudjema, Service de Chirurgie Hepatobilaire, CHU Rennes, University Rennes, Rennes 35033, France
Christophe Camus, Service de Réanimation médicale, CHU Rennes, University Rennes, Rennes 35033, France
Martine Ropert-Bouchet, Laboratoire de biochimie, CHU Rennes, University Rennes, Rennes 35033, France
Author contributions: Bardou-Jacquet E contributed to study design and supervision; Fallet E and Bardou-Jacquet E drafted the manuscript; Fallet E, Uguen T and Rayar M gathered the Data; Bardou-Jacquet E and Rayar M performed statistical analysis; Landrieux A, Camus C, Houssel-Debry P, Jezequel C and Legros L managed the patients; all authors critically revised the manuscript.
Institutional review board statement: This study was approved by the Rennes University Ethics Committee on the 20th of October 2015.
Informed consent statement: According to this law (Loi Jardé n° 2012-300 the 5th of March 2012) the retrospective use of clinical and biological data generated during the routine car of patient does not require signed informed consent for patients included in this kind of study.
Conflict-of-interest statement: Authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Edouard Bardou-Jacquet, MD, PhD, Professor of Medicine, Service des Maladies du Foie, CHU Rennes, University Rennes, CIC1414, Rennes 35033, France.
Received: December 30, 2019
Peer-review started: December 30, 2019
First decision: January 19, 2020
Revised: March 30, 2020
Accepted: April 17, 2020
Article in press: April 17, 2020
Published online: April 28, 2020
Core Tip

Core tip: Iron is an essential element for many biological functions. Its deficiency or overload is associated with poor outcomes in many settings. Few data are available in patients undergoing liver transplantation, and more specifically on infection related deaths. Our study is the first to describe in a large number of patients, the impact or iron metabolism imbalance on mortality after liver transplantation. Our results show that both iron deficiency and overload are significantly associated with increased mortality. Further we show that transferrin saturation higher than 75% is associated with mortality.