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Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2020; 26(16): 1879-1887
Published online Apr 28, 2020. doi: 10.3748/wjg.v26.i16.1879
Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system
Katherine Roth, Jenna Strickland, Bryan L Copple
Katherine Roth, Jenna Strickland, Bryan L Copple, Department of Pharmacology and Toxicology, Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, United States
Author contributions: Roth K, Strickland J and Copple BL wrote the paper.
Supported by National Institutes of Health Grant, No. DK073566 (to Copple BL); and National Institutes of Health Training Grant, No. ES007255 (to Roth K and Strickland J).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bryan L Copple, PhD, Associate Professor, Research Associate, Department of Pharmacology and Toxicology, Institute for Integrative Toxicology, Michigan State University, 1355 Bogue Street, East Lansing, MI 48824, United States. copple@msu.edu
Received: January 7, 2020
Peer-review started: January 7, 2020
First decision: March 6, 2020
Revised: March 31, 2020
Accepted: April 8, 2020
Article in press: April 8, 2020
Published online: April 28, 2020
Processing time: 111 Days and 13.5 Hours
Core Tip

Core tip: Macrophages contribute to repair of the liver after injury. After injury, Kupffer cells release cytokines that recruit monocyte-derived macrophages that phagocytose dead cell debris. These cells switch phenotype becoming pro-restorative macrophages that terminate cytokine synthesis and produce pro-mitogenic growth factors that facilitate liver repair.