Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2020; 26(15): 1775-1791
Published online Apr 21, 2020. doi: 10.3748/wjg.v26.i15.1775
Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy
Zhen-Yang Li, Hui-Fen Li, Ying-Ying Zhang, Xue-Lan Zhang, Bing Wang, Jiang-Ting Liu
Zhen-Yang Li, Hui-Fen Li, Ying-Ying Zhang, Xue-Lan Zhang, Jiang-Ting Liu, Department of Scientific Research, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
Bing Wang, Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Liu JT and Li ZY performed the majority of experiments and analyzed the data; Li HF and Zhang YY performed the molecular investigations; Zhang XL and Wang B designed and coordinated the research; Li ZY and Li HF wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Qilu Hospital of Shandong University Ethics Committee.
Informed consent statement: All patients in our study provided informed consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jiang-Ting Liu, PhD, Professor, Department of Scientific Research, Shandong University of Traditional Chinese Medicine, No. 4655, Changqing District, Jinan 250355, Shandong Province, China.
Received: December 11, 2019
Peer-review started: December 11, 2019
First decision: January 13, 2020
Revised: January 23, 2020
Accepted: March 19, 2020
Article in press: March 19, 2020
Published online: April 21, 2020
Core Tip

Core tip: This study investigated the clinical value of the long non-coding RNA Rpph1 in esophageal cancer, and analyzed the relationship between Rpph1 and the pathological parameters and prognosis of esophageal cancer. We also studied the effect of Rpph1 on the sensitivity of esophageal cancer to radiotherapy, on cell apoptosis, proliferation, migration, and cell cycle, as well as its effect on epithelial-mesenchymal transition-related proteins.