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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2019; 25(9): 1050-1066
Published online Mar 7, 2019. doi: 10.3748/wjg.v25.i9.1050
Published online Mar 7, 2019. doi: 10.3748/wjg.v25.i9.1050
Reaction of antibodies to Campylobacter jejuni and cytolethal distending toxin B with tissues and food antigens
Aristo Vojdani, Immunosciences Lab., Inc., Los Angeles, CA 90035, United States
Aristo Vojdani, Cyrex Labs, LLC., Phoenix, AZ 85034, United States
Aristo Vojdani, Department of Preventive Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92354, United States
Elroy Vojdani, Regenera Medical, Los Angeles, CA 90025, United States
Author contributions: Vojdani A performed the majority of the experiments, analyzed the data, and wrote the article; Vojdani E also performed some of the experiments and helped in the preparation of the article.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have checked the manuscript according to the ARRIVE guidelines.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Aristo Vojdani, MSc, PhD, Doctor, Reader (Associate Professor), Research Scientist, Immunosciences Lab., Inc., 822 S. Robertson Blvd., Ste. 312, Los Angeles, CA 90035, United States. drari@msn.com
Telephone: +1-310-6571077 Fax: +1-310-6571053
Received: November 15, 2018
Peer-review started: November 15, 2018
First decision: January 11, 2019
Revised: January 16, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: March 7, 2019
Peer-review started: November 15, 2018
First decision: January 11, 2019
Revised: January 16, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: March 7, 2019
Core Tip
Core tip: In a search for a possible mechanism for the involvement of Campylobacter jejuni (C. jejuni) in irritable bowel syndrome, inflammatory bowel disease, reactive arthritis, Guillane-Barré syndrome and other disorders, we examined the immunoreactivity of C. jejuni-specific antibodies with a variety of human tissues and food antigens. We found that C. jejuni antibodies showed a significant level of immune reaction with many human tissues and food antigens. These results may open new avenues of research in investigating the role of this bacteria in multiple autoimmunities beyond the gastrointestinal tract.