Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2019; 25(6): 707-718
Published online Feb 14, 2019. doi: 10.3748/wjg.v25.i6.707
Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors
Yuko Hara, Kenichi Goda, Akira Dobashi, Tomohiko Richard Ohya, Masayuki Kato, Kazuki Sumiyama, Takehiro Mitsuishi, Shinichi Hirooka, Masahiro Ikegami, Hisao Tajiri
Yuko Hara, Akira Dobashi, Tomohiko Richard Ohya, Kazuki Sumiyama, Department of Endoscopy, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Kenichi Goda, Department of Gastroenterology, Dokkyo Medical University, Tochigi 321-0293, Japan
Masayuki Kato, Department of Endoscopy, The Jikei University Katsushika Medical Center, Tokyo 125-8506, Japan
Takehiro Mitsuishi, Shinichi Hirooka, Masahiro Ikegami, Department of Pathology, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Hisao Tajiri, Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo 105-8461, Japan
Author contributions: All authors helped to perform the research; Hara Y, Goda K, Dobashi A, and Ohya TR performed the endoscopic procedure; Hara Y and Kato M analyzed and interpreted the data; Hara Y drafted the article; Goda K designed the research; Dobashi A, Ohya TR, Mistuishi T and Hirooka S collected the data; Mistuishi T and Hirooka S performed the pathological diagnosis; Hara Y, Goda K, Sumiyama K, Ikegami M and Tajiri H contributed to critical revision of the article for important intellectual content; Tajiri H provided the final approval for this article.
Institutional review board statement: This study protocol was approved by the Institutional Review Board of the Jikei University School of Medicine, Tokyo, Japan, for clinical research [Registration No.: 29-079 (8695)].
Informed consent statement: This study was a retrospective observational study and carried out by the opt-out method to post a purpose in the Jikei University School of Medicine. Patients were not required to give informed consent for the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. For full disclosure, the details of the study are mentioned in the opt-put document in the Jikei University School of Medicine.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yuko Hara, MD, Research Associate, Department of Endoscopy, The Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, Minato-ku, Tokyo 105-8461, Japan. yukohara0526@yahoo.co.jp
Telephone: +81-3-34331111-3181 Fax: +81-3-34594524
Received: October 13, 2018
Peer-review started: October 14, 2018
First decision: November 7, 2018
Revised: December 31, 2018
Accepted: January 9, 2019
Article in press: January 9, 2019
Published online: February 14, 2019
Processing time: 125 Days and 4.3 Hours
Core Tip

Core tip: Endoscopic resection (ER) in the duodenum remains a challenging technique owing to the anatomical peculiarity associated with the procedure and the high frequency of adverse events. This study aimed to investigate the curability, including long-term outcomes, related to ER for superficial non-ampullary duodenal epithelial tumors (SNADETs) in a large case series. In contrast to endoscopic submucosal dissection (ESD), endoscopic mucosal resection (EMR) was not associated with any adverse events. Nevertheless, ER is expected to provide good long-term outcomes in patients with SNADETs. In conclusion, EMR should be considered as standard treatment for small lesions of SNADETs; however, ESD remains challenging.