Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2019; 25(6): 683-695
Published online Feb 14, 2019. doi: 10.3748/wjg.v25.i6.683
Published online Feb 14, 2019. doi: 10.3748/wjg.v25.i6.683
Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet
Yi-Fan Miao, Hong-Xin Kang, Juan Li, Yu-Mei Zhang, Hong-Yu Ren, Lv Zhu, Huan Chen, Ling Yuan, Hang Su, Mei-Hua Wan, Wen-Fu Tang, Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Tang WF and Li J designed the research; Miao YF, Kang HX, Li J, Zhang YM, Ren HY, Zhu L, Chen H, Yuan L, and Su H performed the research; Miao YF, Kang HX, and Li J analyzed the data; Wan MH contributed new reagents or analytic tools; Miao YF and Kang HX wrote the paper.
Supported by the National Natural Science Foundation of China , No. 81603519 and No. 81573857 .
Institutional review board statement: This study was reviewed and approved by the Institutional Animal Care and Use Committee of West China Hospital of Sichuan University.
Institutional animal care and use committee statement: All rats were handled according to the University Guidelines and the Animal Care Committee Guidelines of West China Hospital (Chengdu, China) (protocol number, 2017052A).
Conflict-of-interest statement: None of the authors have any conflicts of interest to declare.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wen-Fu Tang, PhD, Professor, Department of Integrative Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. tangwf@scu.edu.cn
Telephone: +86-28-85423546 Fax: +86-28-85423373
Received: November 14, 2018
Peer-review started: November 14, 2018
First decision: December 28, 2018
Revised: January 10, 2019
Accepted: January 20, 2019
Article in press: January 21, 2019
Published online: February 14, 2019
Processing time: 94 Days and 4.9 Hours
Peer-review started: November 14, 2018
First decision: December 28, 2018
Revised: January 10, 2019
Accepted: January 20, 2019
Article in press: January 21, 2019
Published online: February 14, 2019
Processing time: 94 Days and 4.9 Hours
Core Tip
Core tip: Obesity worsens inflammatory organ injury in acute pancreatitis (AP), but there is no effective strategy. Sheng-jiang powder (SJP) has been shown to alleviate obesity-induced multiple-organ inflammatory injury. This study demonstrates that obesity may aggravate the inflammatory reaction and pathological injury in multiple organs in AP rats and that SJP may alleviate multiple-organ inflammatory injury in AP in rats fed a high-fat diet.