Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2019; 25(6): 644-658
Published online Feb 14, 2019. doi: 10.3748/wjg.v25.i6.644
Evolving role of magnetic resonance techniques in primary sclerosing cholangitis
Emmanuel A Selvaraj, Emma L Culver, Helen Bungay, Adam Bailey, Roger W Chapman, Michael Pavlides
Emmanuel A Selvaraj, Michael Pavlides, Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Emmanuel A Selvaraj, Emma L Culver, Adam Bailey, Roger W Chapman, Michael Pavlides, Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Emmanuel A Selvaraj, Emma L Culver, Adam Bailey, Michael Pavlides, Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford OX3 9DU, United Kingdom
Helen Bungay, Department of Radiology, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Author contributions: All authors have contributed to write, revise and submit this review.
Supported by the National Institute of Health Research (NIHR) Biomedical Research Centre, based at Oxford University Hospitals NHS Foundation Trust; and Oxfordshire Health Service Research Committee (OHSRC) as part of Oxford Hospitals Charity, Oxford.
Conflict-of-interest statement: Pavlides M is a shareholder for the company Perspectum Diagnostics and has applied for a patent for medical imaging. All other authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Michael Pavlides, BSc, DPhil, MBBS, MRCP, Doctor, Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Level 0, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, United Kingdom. michael.pavlides@cardiov.ox.ac.uk
Telephone: +44-1865-234577
Received: November 28, 2018
Peer-review started: November 28, 2018
First decision: January 18, 2019
Revised: January 25, 2019
Accepted: January 28, 2019
Article in press: January 28, 2019
Published online: February 14, 2019
Processing time: 78 Days and 16.5 Hours
Core Tip

Core tip: Magnetic resonance imaging/magnetic resonance cholangiopancreatography (MRI/MRCP) remains the cornerstone in the diagnosis and follow-up of primary sclerosing cholangitis (PSC) patients. However, heterogeneity in acquisition, image processing and interpretation varies significantly. There is ongoing interest in establishing non-invasive methods to predict clinical endpoints in PSC. A number of recent publications have focused on objectively quantifying output from various magnetic resonance (MR) techniques and have suggested MR parameters as potential prognostic risk-stratification tool in PSC. Our aim is to revisit the historical use of imaging in PSC and consolidate the evolving role of the different MR techniques to date in the quest for establishing a validated imaging biomarker for PSC.