Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2019; 25(5): 622-631
Published online Feb 7, 2019. doi: 10.3748/wjg.v25.i5.622
Hepatocellular carcinoma: Can LI-RADS v2017 with gadoxetic-acid enhancement magnetic resonance and diffusion-weighted imaging improve diagnostic accuracy?
Tong Zhang, Zi-Xing Huang, Yi Wei, Han-Yu Jiang, Jie Chen, Xi-Jiao Liu, Li-Kun Cao, Ting Duan, Xiao-Peng He, Chun-Chao Xia, Bin Song
Tong Zhang, Zi-Xing Huang, Yi Wei, Han-Yu Jiang, Jie Chen, Xi-Jiao Liu, Li-Kun Cao, Ting Duan, Xiao-Peng He, Chun-Chao Xia, Bin Song, Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, Sichuan Province, China
Author contributions: Zhang T, Wei Y, and Song B designed the research; Zhang T, Huang ZX, Jiang HY, and Chen J conducted literature search and analysis; Liu XJ, Cao Lk, Duan T, He XP, and Xia CC provided material support; Song B provided funding for the article; Zhang T and Huang ZX wrote the paper.
Supported by National Natural Science Foundation of China, No. 81471658; and Science and Technology Support Program of Sichuan Province, No. 2017SZ0003.
Institutional review board statement: This study was approved by the Ethics Committee of West China Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because this retrospective study used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bin Song, MD, Chief Doctor, Doctor, Professor, Department of Radiology, Sichuan University West China Hospital, No. 37, Guoxue Alley, Chengdu 610041, Sichuan Province, China. anicesong@vip.sina.com
Telephone: +86-28-85423680 Fax: +86-28-85582499
Received: October 19, 2018
Peer-review started: October 19, 2018
First decision: December 20, 2018
Revised: December 25, 2018
Accepted: January 14, 2019
Article in press: January 14, 2019
Published online: February 7, 2019
Core Tip

Core tip: The aim of this study was to determine whether the use of diffusion-weighted imaging (DWI) improves the diagnostic efficiency of the Liver Imaging Reporting and Data System (LI-RADS) v2017 with gadoxetic acid-enhanced magnetic resonance (MR) for hepatocellular carcinoma (HCC). A total of 245 observations in 203 patients were analyzed. The Youden index values of the LI-RADS classification without or with DWI were as follows: LR-4/5: 0.539 vs 0.679; LR-4/5/M: 0.346 vs 0.467; and LR-4/5/TIV: 0.508 vs 0.647. Using LI-RADS v2017 with gadoxetic acid-enhanced MR combined with DWI may result in a more accurate diagnosis of HCC.