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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2019; 25(5): 600-607
Published online Feb 7, 2019. doi: 10.3748/wjg.v25.i5.600
Published online Feb 7, 2019. doi: 10.3748/wjg.v25.i5.600
Zinc deficiency in patients with chronic pancreatitis
Miroslav Vujasinovic, Aleksandra Hedström, Roberto Valente, J-Matthias Löhr, Stephan L Haas, Department for Digestive Diseases, Karolinska University Hospital, Stockholm 14186, Sweden
Patrick Maisonneuve, Division of Epidemiology and Biostatistics, IEO, European Institute of Oncology IRCCS, Milan 20141, Italy
Roberto Valente, Department for Digestive Diseases, Sapienza University of Rome, Rome 00185, Italy
Henrik von Horn, Division of Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm 14186, Sweden
J-Matthias Löhr, Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institute, Stockholm 14186, Sweden
Author contributions: Vujasinovic M and Löhr JM designed the research; Vujasinovic M collected the data; von Horn H oversaw laboratory analysis; Maisonneuve P performed statistics; all authors wrote the paper; Hedström A, Valente R and Haas SL critically revised the manuscript for important intellectual content.
Institutional review board statement: The study was approved by the Stockholm Ethic Committee (SLL), numbers 2014/1094-31, 2016/491-3172 and 2016/1571-31.
Informed consent statement: We performed retrospective analysis of data and informed consent was not obtained.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
STROBE statement: The authors have read the STROBE Statement - checklist of items, and the manuscript was prepared and revised according to the STROBE Statement - checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Miroslav Vujasinovic, MD, PhD, Doctor, Department for Digestive Diseases, Karolinska University Hospital, Hälsovägen 11, Stockholm 14186, Sweden. miroslav.vujasinovic@sll.se
Telephone: +46-724694938 Fax: +46-858582335
Received: December 6, 2018
Peer-review started: December 6, 2018
First decision: December 28, 2018
Revised: January 10, 2019
Accepted: January 14, 2019
Article in press: January 14, 2019
Published online: February 7, 2019
Peer-review started: December 6, 2018
First decision: December 28, 2018
Revised: January 10, 2019
Accepted: January 14, 2019
Article in press: January 14, 2019
Published online: February 7, 2019
Core Tip
Core tip: Normal levels of zinc are pivotal to maintain a homeostasis in a wide variety of important cellular systems and immune response. Chronic pancreatitis (CP) is a chronic inflammation of the pancreas resulting in pancreatic exocrine insufficiency, which is associated with malnutrition. There are conflicting published results of zinc levels in patients with CP. Most of the studies were restricted to patients with alcoholic etiology of CP and had limitations due to the small number of studied patients. We are presenting the results of the largest study so far comparing serum zinc levels in relation to different etiological groups of CP.