Shao S, Zhou NM, Dai DQ. Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in gastric cancer. World J Gastroenterol 2019; 25(46): 6713-6727 [PMID: 31857774 DOI: 10.3748/wjg.v25.i46.6713]
Corresponding Author of This Article
Dong-Qiu Dai, MD, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastroenterological Surgery, the Fourth Affiliated Hospital of China Medical University, 4 Chongshan Road, Shenyang 110032, Liaoning Province, China. daidq63@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 14, 2019; 25(46): 6713-6727 Published online Dec 14, 2019. doi: 10.3748/wjg.v25.i46.6713
Aberrant methylation of secreted protein acidic and rich in cysteine gene and its significance in gastric cancer
Shuai Shao, Nuo-Ming Zhou, Dong-Qiu Dai
Shuai Shao, Nuo-Ming Zhou, Dong-Qiu Dai, Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
Author contributions: Dai DQ designed this study; Shao S and Zhou NM performed the research and conducted the data analysis; Shuai S wrote the article; All authors read and approved the final version.
Supported bythe Natural Science Foundation of Liaoning Province, No. 201602817.
Institutional review board statement: The data of gastric cancer we analyzed in this research are all from The Fourth Affiliated Hospital of China Medical University. And our research had been approved by The Fourth Affiliated Hospital of China Medical University Clinical Research Ethics Committee.
Conflict-of-interest statement: All authors declare that there is no conflict of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dong-Qiu Dai, MD, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastroenterological Surgery, the Fourth Affiliated Hospital of China Medical University, 4 Chongshan Road, Shenyang 110032, Liaoning Province, China. daidq63@163.com
Telephone: +86-24-62043110 Fax: +86-24-62043110
Received: August 13, 2019 Peer-review started: August 13, 2019 First decision: September 10, 2019 Revised: September 28, 2019 Accepted: October 22, 2019 Article in press: October 22, 2019 Published online: December 14, 2019 Processing time: 122 Days and 22 Hours
Core Tip
Core tip: We identified four gastric cancer (GC) cell lines and 66 paired tissues using quantitative real-time polymerase chain reaction, western blotting, and methylation-specific polymerase chain reaction. Correlation analysis between expression and clinicopathological features revealed that low expression levels of secreted protein acidic and rich in cysteine (SPARC) and high levels of methylation in GC tissues were associated with poor clinical features and a poor prognosis (high TNM stage and poor differentiation grade). The restoration of SPARC suppressed GC cell proliferation, migration, and invasion, arrested the cell cycle, and increased apoptosis. Our study found that SPARC represents a potential target for treating GC individuals.
