Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2019; 25(44): 6551-6560
Published online Nov 28, 2019. doi: 10.3748/wjg.v25.i44.6551
Real life efficacy and safety of direct-acting antiviral therapy for treatment of patients infected with hepatitis C virus genotypes 1, 2 and 3 in northwest China
Ying Yang, Feng-Ping Wu, Wen-Jun Wang, Juan-Juan Shi, Ya-Ping Li, Xin Zhang, Shuang-Suo Dang
Ying Yang, Feng-Ping Wu, Wen-Jun Wang, Juan-Juan Shi, Ya-Ping Li, Xin Zhang, Shuang-Suo Dang, Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Author contributions: Yang Y, Wu FP, Shi JJ, Li YP and Zhang X collected the data; Yang Y analyzed the data and wrote the paper; Dang SS and Wang WJ reviewed the manuscript; all authors read and approved the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board of Xi’an Jiaotong University.
Informed consent statement: All study participants, or their legal guardian, provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors do not have any conflict of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items and the manuscript was prepared and revised accordingly.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shuang-Suo Dang, MD, PhD, Academic Fellow, Academic Research, Doctor, Professor, Department of Infectious Diseases, the Second Affiliated Hospital of Xi’an Jiaotong University, 157 Xiwu Road, Xincheng District, Xi’an 710004, Shaanxi Province, China. dangshuangsuo123@xjtu.edu.cn
Telephone: +86-29-87679688
Received: September 6, 2019
Peer-review started: September 6, 2019
First decision: October 14, 2019
Revised: November 8, 2019
Accepted: November 13, 2019
Article in press: November 13, 2019
Published online: November 28, 2019
Processing time: 83 Days and 6.7 Hours
Core Tip

Core tip: Direct-acting antiviral agent (DAA)-based regimens are currently the preferred treatment for hepatitis C. However, there is not enough data reporting the results of real-world research, especially in countries such as China where DAAs have only been approved for using in recent years. We found that there was no significant difference in sustained virological responses (SVR) between patients with different genotypes and liver statuses. Patients with lower alanine aminotransferase levels at baseline who achieved end of treatment response were more likely to achieve SVR at post-treatment week 12. Also, we found two cases of special adverse events. One case involved facial and bilateral lower extremity edema, which was due to drug-drug interactions, and the other case showed an interesting change in lipid levels while the patient was on medication.