Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2019; 25(44): 6495-6507
Published online Nov 28, 2019. doi: 10.3748/wjg.v25.i44.6495
Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling
Seol-Hee Han, Ji-Su Mo, Won-Cheol Park, Soo-Cheon Chae
Seol-Hee Han, Ji-Su Mo, Soo-Cheon Chae, Department of Pathology, School of Medicine, Wonkwang University, Iksan, Chonbuk 54538, South Korea
Ji-Su Mo, Won-Cheol Park, Soo-Cheon Chae, Digestive Disease Research Institute, Wonkwang University, Iksan, Chonbuk 54538, South Korea
Author contributions: Chae SC conceived and designed the experiments; Han SH and Mo JS performed the experiments; Han SH and Chae SC analyzed the data; Park WC and Chae SC contributed reagents/materials/analysis tools, and drafted the manuscript.
Supported by a grant from the National Research Foundation of Korea, No. 2017R1A2B4004801.
Institutional review board statement: The study was reviewed and approved by the Review Board of Wonkwang University, South Korea (WKIRB-201710-BR-012).
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: This study was prepared according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Soo-Cheon Chae, PhD, Professor of Medicine, Department of Pathology, School of Medicine, Wonkwang University, Iksan, Chonbuk 54538, South Korea.
Telephone: +82-63-8506793 Fax: +82-63-8506760
Received: October 10, 2019
Peer-review started: October 10, 2019
First decision: November 10, 2019
Revised: November 20, 2019
Accepted: November 23, 2019
Article in press: November 23, 2019
Published online: November 28, 2019
Core Tip

Core tip: The microRNA 375 (MIR375) is significantly downregulated in human colorectal cancer (CRC) tissues. In this study, we investigated that metadherin (MTDH) is a direct target gene of MIR375 and that MTDH expression levels were upregulated in CRC tissues. Upregulated MTDH expression levels were found to inhibit NF-κB inhibitor alpha expression, which further upregulated NFKB1 and RELA expression in CRC cells. MIR375 also regulate MTDH-mediated BRAF-MAPK and PIK3CA-AKT signal pathways in CRC cells. Consequently, MIR375 regulates cell proliferation, cell migration, and angiogenesis by suppressing MTDH expression in CRC progression.