Wu YL, Li ZL, Zhang XB, Liu H. Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing protein kinase RNA-like endoplasmic reticulum kinase-induced pathway. World J Gastroenterol 2019; 25(41): 6205-6221 [PMID: 31749592 DOI: 10.3748/wjg.v25.i41.6205]
Corresponding Author of This Article
Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, No. 6, Changjiang Street, Nankai District, Tianjin 300100, China. nkyylzl@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 7, 2019; 25(41): 6205-6221 Published online Nov 7, 2019. doi: 10.3748/wjg.v25.i41.6205
Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing protein kinase RNA-like endoplasmic reticulum kinase-induced pathway
Yan-Li Wu, Zhong-Lian Li, Xi-Bo Zhang, Hao Liu
Yan-Li Wu, Graduate School of Tianjin Medical University, Tianjin 300070, China
Zhong-Lian Li, Xi-Bo Zhang, Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin 300100, China
Hao Liu, Graduate School of Tianjin Medical University, Tianjin 300070, China.
Author contributions: Wu YL and Li ZL designed the research; Wu YL and Liu H performed the research; Wu YL and Zhang XB analyzed the data; Wu YL and Li ZL composed the paper.
Supported bythe National Natural Science Foundation of China, No. 81273952.
Institutional animal care and use committee statement: The experimental protocol was approved by the Animal Research Committee of Tianjin Nankai Hospital.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines and prepared the manuscript accordingly.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, No. 6, Changjiang Street, Nankai District, Tianjin 300100, China. nkyylzl@163.com
Telephone: +86-22-27435237 Fax: +86-22-27435237
Received: August 8, 2019 Peer-review started: August 8, 2019 First decision: September 18, 2019 Revised: September 26, 2019 Accepted: October 17, 2019 Article in press: October 17, 2019 Published online: November 7, 2019 Processing time: 90 Days and 16 Hours
Core Tip
Core tip: Chronic biliary obstruction results in ischaemia and hypoxia of hepatocytes and leads to apoptosis. The protein kinase RNA-like endoplasmic reticulum kinase (PERK)-induced apoptotic pathway is the main and important way, however, its role in liver injury and hepatocyte apoptosis remains unclear. Yinchenhao decoction (YCHD) can alleviate liver injury and apoptosis, but whether YCHD can attenuates obstructive jaundice (OJ)-induced liver injury and hepatocyte apoptosis by inhibiting the PERK-induced pathway is still unknown. In this research study, we found that OJ induced liver injury and hepatocyte apoptosis by activating the PERK- CCAAT/enhancer-binding protein homologous protein (CHOP)-growth arrest and DNA damage-inducible protein 34 (GADD34) pathway and upregulating the B cell lymphoma/leukemia-2 related X protein (Bax)/ B cell lymphoma/leukemia-2 (Bcl-2) ratio. YCHD attenuated these changes by inhibiting the PERK-CHOP-GADD34 pathway and Bax/Bcl-2 ratio.
