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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2019; 25(39): 5953-5960
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5953
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5953
Gender differences in vascular reactivity of mesenteric arterioles in portal hypertensive and non-portal hypertensive rats
Bin Zhang, Lin-Hua Ji, Cheng-Gang Zhang, Gang Zhao, Zhi-Yong Wu, Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Author contributions: Zhang B, Zhao G, and Wu ZY designed the research; Ji LH, Zhang B, and Zhang CG performed the research; Zhang B and Zhang CG analyzed the data; Ji LH and Zhang B wrote the paper.
Supported by the National Natural Science Foundation for the Youth of China , No. 81400630
Institutional review board statement: The study was reviewed and approved by Renji Hospital Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Renji Hospital (IACUC protocol number: RJ-20151211).
Conflict-of-interest statement: The authors declare that there is no conflict of interest to be disclosed.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The ARRIVE Guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Gang Zhao, MD, PhD, Chief Doctor, Surgeon, Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 Pujian Road, Shanghai 200127, China. zhaogang@renji.com
Telephone: +86-21-68383732 Fax: +86-21-68383090
Received: July 25, 2019
Peer-review started: July 25, 2019
First decision: August 17, 2019
Revised: August 28, 2019
Accepted: September 9, 2019
Article in press: September 9, 2019
Published online: October 21, 2019
Processing time: 87 Days and 21.2 Hours
Peer-review started: July 25, 2019
First decision: August 17, 2019
Revised: August 28, 2019
Accepted: September 9, 2019
Article in press: September 9, 2019
Published online: October 21, 2019
Processing time: 87 Days and 21.2 Hours
Core Tip
Core tip: In cirrhosis, extrahepatic vascular hypocontractility leads to splanchnic vasodilation and decreased splanchnic vascular resistance. In this study, clear gender differences were observed in mesenteric vascular reactivity in carbon tetrachloride-induced cirrhotic and portal hypertensive rats. Conservation of estrogen can retain the sensitivity of mesenteric arterioles to vasoconstrictors and has a protective effect on splanchnic vascular function in portal hypertension.