STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
Mohamed T Khayyal, Walaa Wadie, Enas A Abd El-Haleim, Kawkab A Ahmed, Olaf Kelber, Ramy M Ammar, Heba Abdel-Aziz
Mohamed T Khayyal, Walaa Wadie, Enas A Abd El-Haleim, Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
Kawkab A Ahmed, Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Cairo 12211, Egypt
Olaf Kelber, Ramy M Ammar, Heba Abdel-Aziz, Steigerwald Arzneimittelwerk GmbH, Bayer Consumer Health, Darmstadt 64295, Germany
Ramy M Ammar, Department of Pharmacology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33511, Egypt
Author contributions: Khayyal MT, Wadie W, Abd El-Haleim EA carried out the experimental study; Ahmed KA performed the histological part; Kelber O, Ammar RM, Abdel-Aziz H was responsible for planning of the study; all authors involved in writing and revising the manuscript.
Institutional animal care and use committee statement: The study was approved by the Ethical Committee for experimentation with laboratory animals (Faculty of Pharmacy, Cairo University) following the revised guidelines of the European Economic Community regulations (86/609/EEC) (Permit Number: PT 2292).
Conflict-of-interest statement: Mohamed T Khayyal reports grants from Steigerwald Arzneimittelwerk GmbH, Bayer Consumer Health, during the conduct of the study; Olaf Kelber, Ramy M. Ammar, Heba Abdel-Aziz are employed by Steigerwald Arzneimittelwerk GmbH, Bayer Consumer Health, Darmstadt, Germany; all other authors have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mohamed T Khayyal, PhD, Professor, Department of Pharmacology, Faculty of Pharmacy, Cairo University, Kasr-El-Aini Street, Cairo 11562, Egypt. mtkhayyal@gmail.com
Telephone: +20-1-222102644 Fax: +20-2-37743491
Received: April 28, 2019
Peer-review started: April 28, 2019
First decision: July 22, 2019
Revised: August 16, 2019
Accepted: September 13, 2019
Article in press: September 13, 2019
Published online: October 21, 2019
