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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2019; 25(39): 5918-5925
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5918
Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.5918
Role of tristetraprolin phosphorylation in paediatric patients with inflammatory bowel disease
Alessia Di Silvestre, Letizia Pugnetti, PhD School in Science of Reproduction and Development, University of Trieste, Trieste 34127, Italy
Marianna Lucafò, Matteo Bramuzzo, Egidio Barbi, Giuliana Decorti, Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste 34137, Italy
Gabriele Stocco, Department of Life Sciences, University of Trieste, Trieste 34127, Italy
Egidio Barbi, Giuliana Decorti, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste 34127, Italy
Author contributions: Di Silvestre A and Decorti G contributed to the conception and design of the study; Di Silvestre A and Pugnetti L collected the data; Di Silvestre A, Lucafò M, Bramuzzo M performed data analysis and interpretation; Di Silvestre A drafted the article; Lucafò M, Stocco G, Barbi E and Decorti G critically reviewed the article.
Supported by the Italian Ministry of Health projects Ricerca Corrente 1/17 and 21/17 (Institute for Maternal and Child Health IRCCS Burlo Garofolo) .
Institutional review board statement: The study was reviewed and approved by the Ethical Committee of the Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste, Italy.
Conflict-of-interest statement: The authors declare no competing financial, personal or professional conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The ARRIVE guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Giuliana Decorti, MD, Full Professor, Department of Medical, Surgical and Health Sciences, University of Trieste, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Via A. Fleming 22, Trieste, I-34127, Italy. decorti@units.it
Telephone: +39-40-5588777
Received: August 1, 2019
Peer-review started: August 1, 2019
First decision: August 27, 2019
Revised: September 6, 2019
Accepted: September 27, 2019
Article in press: September 27, 2019
Published online: October 21, 2019
Processing time: 80 Days and 20.4 Hours
Peer-review started: August 1, 2019
First decision: August 27, 2019
Revised: September 6, 2019
Accepted: September 27, 2019
Article in press: September 27, 2019
Published online: October 21, 2019
Processing time: 80 Days and 20.4 Hours
Core Tip
Core tip: We report a preliminary study describing the role of tristetraprolin (TTP)/14-3-3 protein complex in a small cohort of paediatric patients affected by inflammatory bowel disease (IBD). The experiments were conducted on IBD inflamed and non-inflamed colonic tissues and in IBD-derived macrophages in comparison to healthy donors. This study demonstrates for the first time the relation between the phosphorylation of TTP and IBD in paediatric patients. Indeed, a higher expression of the TTP/14-3-3 protein complex was recorded both in inflamed compared to non-inflamed colon specimens and in IBD-derived in comparison to healthy donors’ macrophages.