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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2019; 25(37): 5687-5701
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5687
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5687
Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging
Breno Boueri Affonso, Francisco Leonardo Galastri, Joaquim Mauricio da Motta Leal Filho, Felipe Nasser, Priscila Mina Falsarella, Rafael Noronha Cavalcante, Leonardo Guedes Moreira Valle, Department of Interventional Radiology, Hospital Israelita Albert Einstein, São Paulo 05651-901, São Paulo, Brazil
Marcio Dias de Almeida, Guilherme Eduardo Gonçalves Felga, Department of Liver Transplant, Hospital Israelita Albert Einstein, São Paulo 05651-901, São Paulo, Brazil
Nelson Wolosker, Department of Vascular Surgery, Hospital Israelita Albert Einstein, São Paulo 05651-901, São Paulo, Brazil
Author contributions: da Motta Leal Filho JM and Nasser F designed research/study; Affonso BB, Galastri FL, da Motta Leal Filho JM, Nasser F, Falsarella PM, Cavalcante RN, and Wolosker N performed research/study; Affonso BB, Galastri FL, Falsarella PM, de Almeida MD, Felga GEG, Valle LGM, and Wolosker N contributed important reagents; Affonso BB, Galastri FL, Nasser F, da Motta Leal Filho JM, Falsarella PM, de Almeida MD, and Valle LGM collected data; Affonso BB, Galastri FL, da Motta Leal Filho JM, Cavalcante RN and Falsarella PM analyzed data; Affonso BB and Valle LGM submit a manuscript; da Motta Leal Filho JM and Cavalcante RN wrote the paper.
Institutional review board statement: Process CEP/Einstein nº11/1704.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: Breno Affonso has no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Breno Boueri Affonso, PhD, Medical Assistant, Research Scientist, Staff Physician, Surgeon, Teacher, Interventional Radiologist, Department of Interventional Radiology, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701, São Paulo 05651-901, São Paulo, Brazil. breno.affonso@einstein.br
Telephone: +55-11-982625115 Fax: +55-11-21510434
Received: June 1, 2019
Peer-review started: June 3, 2019
First decision: July 21, 2019
Revised: August 30, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 7, 2019
Processing time: 121 Days and 7.2 Hours
Peer-review started: June 3, 2019
First decision: July 21, 2019
Revised: August 30, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 7, 2019
Processing time: 121 Days and 7.2 Hours
Core Tip
Core tip: The great finding of this work was that through a homogeneous technique of hepatic chemoembolization with drug eluting beads, it was possible to perform the procedures controlling the drug delivery and end point. In conclusion, as far as the degree of tumor necrosis as well as in relation to survival, there was no difference between the group within the Milan criteria (bridging) and the group outside the criteria (downstaging). Therefore, it is worth investing in the treatment of patients out of the Milan criteria so that they have a survival with the same expectations of the patients in criterion.