Case Control Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2019; 25(37): 5604-5618
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5604
Correlation of plasma miR-21 and miR-93 with radiotherapy and chemotherapy efficacy and prognosis in patients with esophageal squamous cell carcinoma
Wen-Tao Wang, Chang-Qing Guo, Guang-Hui Cui, Song Zhao
Wen-Tao Wang, Guang-Hui Cui, Song Zhao, Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Chang-Qing Guo, Digestive Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Author contributions: Wang WT designed the research; Cui GH performed the research; Wang WT contributed new reagents and analytic tools; Zhao S analyzed the data; Cui GH and Zhao S wrote the paper.
Institutional review board statement: The study was authorized by the Ethics Committee of First Affiliated Hospital of Zhengzhou University.
Informed consent statement: All patients provided written informed consent.
Conflict-of-interest statement: There was no competing interest.
Data sharing statement: All the data in the current research are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Song Zhao, MD, Doctor, Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, No. 1, Longhu Zhonghuan Road, Jinshui District, Zhengzhou 450000, Henan Province, China. zhaosong1212@qq.com
Telephone: +86-371-66913114 Fax: +86-371-66913114
Received: July 24, 2019
Peer-review started: July 24, 2019
First decision: August 18, 2019
Revised: September 8, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 7, 2019
Processing time: 67 Days and 17.4 Hours
Core Tip

Core tip: In order to observe the roles of miR-21 and miR-93 in predicting radiotherapy and chemotherapy efficacy and prognosis in esophageal squamous cell carcinoma (ESCC), quantitative real-time polymerase chain reaction was adopted to determine the expression of plasma miR-21 and miR-93 in ESCC patients. Multivariate Logistic regression analysis revealed that patients with high T stage and M stage and high expression of miR-21 (> 5.80) and miR-93 (> 4.71) suffered an increased risk of ineffective radiotherapy and chemotherapy, and multivariate Cox regression analysis revealed that patients with high T stage, N stage, and M stage, and high expression of miR-21 (> 5.60), and miR-93 (> 3.87) suffered an increased risk of death in 3 years.