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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2019; 25(37): 5578-5589
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5578
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5578
Pathogenesis and clinical management of Helicobacter pylori gastric infection
Breno Bittencourt de Brito, Filipe Antônio França da Silva, Aline Silva Soares, Vinícius Afonso Pereira, Maria Luísa Cordeiro Santos, Mariana Miranda Sampaio, Pedro Henrique Moreira Neves, Fabrício Freire de Melo, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version; All authors agree to be accountable for all aspects of the work in ensuring that questions that related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Conflict-of-interest statement: All authors declare no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Postdoctoral Fellow, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremelo@yahoo.com.br
Telephone: +55-77-991968134
Received: June 15, 2019
Peer-review started: June 17, 2019
First decision: July 21, 2019
Revised: August 14, 2019
Accepted: August 19, 2019
Article in press: July 21, 2019
Published online: October 7, 2019
Peer-review started: June 17, 2019
First decision: July 21, 2019
Revised: August 14, 2019
Accepted: August 19, 2019
Article in press: July 21, 2019
Published online: October 7, 2019
Core Tip
Core tip:Helicobacter pylori (H. pylori) is a bacterium that infects more than half of the world’s population. The mechanisms of such infections are complex and deeply studied. In addition, the clinical outcomes are variable and depend on both pathogen and host characteristics. Moreover, the adequate clinical management by means of proper diagnosis and effective treatment is crucial for reaching success in bacterial eradication. This article aims to provide a broad overview of H. pylori infection, from pathogenesis to clinical management.