Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2019; 25(36): 5434-5450
Published online Sep 28, 2019. doi: 10.3748/wjg.v25.i36.5434
High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition
Ting-Jie Ye, Yan-Lin Lu, Xiao-Feng Yan, Xu-Dong Hu, Xiao-Ling Wang
Ting-Jie Ye, Yan-Lin Lu, Xiao-Feng Yan, Xu-Dong Hu, Xiao-Ling Wang, Department of Biology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Yan-Lin Lu, Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Ye TJ, Lu YL, and Yan XF performed the experiments, collected the data, and prepared the figures and tables; Wang XL and Ye TJ obtained the funding and designed the experiments; Wang XL and Hu XD supervised the project and wrote and finalized the manuscript.
Supported by the National Natural Science Foundation of China, No. 81503367 and No. 81703832.
Institutional review board statement: All procedures involving animals were approved by the Animal Ethics Committee of Shanghai University of Traditional Chinese Medicine.
Institutional animal care and use committee statement: All procedures involving animals were approved by the Animal Ethics Committee of Shanghai University of Traditional Chinese Medicine. (protocol number: PZSHUTCM190419001).
Conflict-of-interest statement: The authors declared that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Ling Wang, MD, Full Professor, Department of Biology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong, Shanghai 201203, China. shengwuwang12@126.com
Telephone: +86-21-51322585
Received: April 26, 2019
Peer-review started: April 26, 2019
First decision: May 24, 2019
Revised: August 7, 2019
Accepted: August 19, 2019
Article in press: August 19, 2019
Published online: September 28, 2019
Core Tip

Core tip: High mobility group box 1 (HMGB1) is a nuclear protein that non-specifically binds to the minor grooves in DNA. Once released passively by necrotic and damaged cells, HMGB1 will become a damage-associated molecular pattern molecule triggering the inflammatory response and ultimately results in tissue damage. In the present study, we found that HMGB1 is released from H2O2-injured hepatocytes due to Sirt1 functional inhibition.