Systematic Reviews
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2019; 25(35): 5356-5375
Published online Sep 21, 2019. doi: 10.3748/wjg.v25.i35.5356
De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature
Tommaso Maria Manzia, Roberta Angelico, Carlo Gazia, Ilaria Lenci, Martina Milana, Oludamilola T Ademoyero, Domiziana Pedini, Luca Toti, Marco Spada, Giuseppe Tisone, Leonardo Baiocchi
Tommaso Maria Manzia, Carlo Gazia, Luca Toti, Giuseppe Tisone, HPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Rome 00133, Italy
Roberta Angelico, Domiziana Pedini, Marco Spada, Division of Abdominal Transplantation and HPB Surgery, Bambino Gesù Children's Hospital IRCCS, Rome 00165, Italy
Carlo Gazia, Oludamilola T Ademoyero, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, United States
Ilaria Lenci, Martina Milana, Leonardo Baiocchi, Hepatology and Liver Transplant Unit, University of Tor Vergata, Rome 00133, Italy
Author contributions: Manzia TM and Angelico R contributed equally to the work, paper conception and design and critical revision; Gazia C, Lenci I, Milana M, Ademoyero OT, Pedini D and Toti L contributed to acquisition of data, analysis and interpretation, drafting of manuscript and critical revision; Spada M, Tisone G and Baiocchi L contributed to study conception and critical revision.
Conflict-of-interest statement: The authors declare they have no conflicts of interest to disclose.
PRISMA 2009 Checklist statement: Authors read the PRISMA 2009 Checklist and the manuscript was prepared and revised according to the PRISMA 2009.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Tommaso Maria Manzia, MD, PhD, Assistant Professor, HPB and Transplant Unit, Department of Surgery, University of Rome Tor Vergata, Viale Oxford, 81, Rome 00133, Italy. tomanzia@libero.it
Telephone: +39-6-20902498
Received: May 2, 2019
Peer-review started: May 4, 2019
First decision: May 30, 2019
Revised: August 8, 2019
Accepted: August 24, 2019
Article in press: August 24, 2019
Published online: September 21, 2019
Processing time: 143 Days and 10.3 Hours
Core Tip

Core tip: A systematic literature examination about de novo malignancies and immunosuppression weaning both in adult and pediatric orthotopic liver transplant recipients was described in the present review. Even though conclusive evidence on immunosuppression withdrawal in orthotopic liver transplant recipients with regard to malignancies are lacking, we can argue that the reconstitution of the immunological pathway could decrease the incidence of de novo malignancies and may also help in treating liver transplant patients suffering from cancers.