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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2019; 25(34): 5105-5119
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5105
Published online Sep 14, 2019. doi: 10.3748/wjg.v25.i34.5105
Regulatory effect of a Chinese herbal medicine formula on non-alcoholic fatty liver disease
Jia-Min Yang, Yan Sun, Min Wang, Xin-Lei Zhang, Shu-Jing Zhang, Yu-Shan Gao, Lin Chen, Meng-Yao Wu, Lu Zhou, Yu-Mei Zhou, Yue Wang, Feng-Jie Zheng, Yu-Hang Li, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Author contributions: Li YH carried out the research and designed the experiments; Yang JM analyzed the data and wrote the manuscript; Wang M, Zhang XL, Zhang SJ, Gao YS, Chen L, Wu MY, Zhou L, Zhou YM, and Wang Y contributed to drug preparation and experimental manipulation; Sun Y and Zheng FJ contributed to experimental instruction and data acquisition.
Supported by the National Natural Science Foundation of China , No. 81673868 .
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Medical and Experimental Animal Ethics Committee of Beijing University of Chinese Medicine (No. BUCM-1-2017051030-2030).
Conflict-of-interest statement: None of the authors have any conflicts of interest relevant to this study.
Data sharing: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yu-Hang Li, PhD, Professor, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, East Beisanhuan Road, Chaoyang District, Beijing 100029, China. liyuhang@bucm.edu.cn
Telephone: +86-10-64287503 Fax: +86-10-53912004
Received: April 12, 2019
Peer-review started: April 12, 2019
First decision: May 24, 2019
Revised: June 14, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: September 14, 2019
Peer-review started: April 12, 2019
First decision: May 24, 2019
Revised: June 14, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: September 14, 2019
Core Tip
Core tip: Based on the previous study about the “intestinal-hepatic axis”, we hypothesized that the effect of Chinese herbal medicine (CHM) on non-alcoholic fatty liver disease is achieved by regulating the liver and intestine. In this study, we found that a CHM formula (a decoction of thorowax root, scutellaria root, and white peony root) had a good effect in regulating lipid metabolism and liver function, which suggested its ability to regulate the liver. To a certain extent, it also had a regulatory effect on the intestinal mucosal barrier. Our study demonstrated that the CHM formula can affect both the liver and intestine, while its effect on the liver is superior to that on the intestine.