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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2019; 25(33): 4921-4932
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4921
Published online Sep 7, 2019. doi: 10.3748/wjg.v25.i33.4921
Identification of hepatitis B virus and liver cancer bridge molecules based on functional module network
Xiao-Bing Huang, Yong-Gang He, Lu Zheng, Yu-Ming Li, Hong-Yan Li, Feng-Xia Yang, Jing Li, Department of Hepatobiliary Surgery, Second Hospital Affiliated to Third Military Medical University of Xinqiao Hospital, Chongqing 400037, China
Huan Feng, Division of Nursing, Second Hospital Affiliated to Third Military Medical University, Xinqiao Hospital, Chongqing 400037, China
Author contributions: Huang XB wrote the majority of the paper, performed experiments, and analyzed the data; He YG, Zheng L, Feng H, Li YM, Li HY, and Yang FX performed experiments and analyzed the data; Li J designed and coordinated the research.
Supported by the Basic and Advanced Research Projects of Chongqing , No. cstc2015jcyjA10123 .
Institutional review board statement: This study was reviewed and approved by the Second Hospital Affiliated to Third Military Medical University of Xinqiao Hospital Ethics Committee.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jing Li, MD, MSc, Attending Doctor, Doctor, Department of Hepatobiliary Surgery, Second Hospital Affiliated to Third Military Medical University of Xinqiao Hospital, Xinqiao street 183, Shapingba District, Chongqing 400037, China. xqyylijing@tom.com
Telephone: +86-23-68755000 Fax: +86-23-68755114
Received: April 25, 2019
Peer-review started: April 25, 2019
First decision: May 30, 2019
Revised: June 29, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: September 7, 2019
Processing time: 135 Days and 20.4 Hours
Peer-review started: April 25, 2019
First decision: May 30, 2019
Revised: June 29, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: September 7, 2019
Processing time: 135 Days and 20.4 Hours
Core Tip
Core tip: The potential role of chronic inflammation in the development of cancer has been widely recognized. However, the molecular link between hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) has not been fully and thoroughly explored. Therefore, this study analyzed the molecular processes of HBV-HCC using a multidimensional approach to elucidate the molecular links between the two groups. The results suggest that the persistent inflammatory environment of HBV can be used as an important risk factor to induce the occurrence of HCC, which is supported by molecular evidence.