Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2019; 25(31): 4360-4382
Published online Aug 21, 2019. doi: 10.3748/wjg.v25.i31.4360
Treatment of hepatocellular carcinoma in patients with portal vein tumor thrombosis: Beyond the known frontiers
Lucia Cerrito, Brigida Eleonora Annicchiarico, Roberto Iezzi, Antonio Gasbarrini, Maurizio Pompili, Francesca Romana Ponziani
Lucia Cerrito, Brigida Eleonora Annicchiarico, Antonio Gasbarrini, Maurizio Pompili, Francesca Romana Ponziani, Division of Internal Medicine, Gastroenterology and Hepatology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Roberto Iezzi, Department of Bioimaging and Radiological Sciences, Institute of Radiology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Author contributions: Cerrito L, Pompili M and Ponziani FR were responsible for manuscript preparation, table design, reference collection and final editing; Annicchiarico BE, Iezzi R and Gasbarrini A contributed to this paper with drafting and critical revision and editing.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Francesca Romana Ponziani, MD, PhD, Doctor, Division of Internal Medicine, Gastroenterology and Hepatology Unit, Fondazione Policlinico Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, Rome 00168, Italy. francesca.ponziani@gmail.com
Telephone: +39-347-1227242
Received: April 22, 2019
Peer-review started: April 22, 2019
First decision: June 10, 2019
Revised: June 24, 2019
Accepted: July 19, 2019
Article in press: July 19, 2019
Published online: August 21, 2019
Processing time: 122 Days and 12.5 Hours
Core Tip

Core tip: Portal vein tumor thrombosis (PVTT) is a complex anatomical and clinical condition, including patients with different prognosis according to the degree of portal system involvement, tumor biological aggressiveness, complications caused by portal hypertension, patient’s clinical features and tolerance to antineoplastic treatments. For this reason, it is extremely important to focus on the most adequate treatment strategy for each group of PVTT patients.