Incidence and treatment of mediastinal leakage after esophagectomy: Insights from the multicenter study on mediastinal leaks
Uberto Fumagalli, Department of Digestive Surgery, IEO European Institute of Oncology IRCCS, Milano 20141, Italy
Gian Luca Baiocchi, Nazario Portolani, Department of Clinical and Experimental Studies, Surgical Clinic, University of Brescia, Brescia 25123, Italy
Andrea Celotti, Stefano de Pascale, General Surgery 2, ASST Spedali Civili di Brescia, Brescia 25123, Italy
Paolo Parise, Andrea Cossu, Department of Gastrointestinal Surgery, San Raffaele Hospital, Vita-Salute San Raffaele University, Milano 20132, Italy
Luigi Bonavina, Daniele Bernardi, Department of Surgery, IRCCS Policlinico San Donato, University of Milan, Milano 20122, Italy
Giovanni de Manzoni, Jacopo Weindelmayer, General and Upper GI Surgery Division, University of Verona, Verona 37134, Italy
Giuseppe Verlato, Department of Diagnostics and Public Health, University of Verona, Verona 37134, Italy
Stefano Santi, Giovanni Pallabazzer, Esophageal Surgery Unit, Tuscany Regional Referral Center for the Diagnosis and Treatment of Esophageal Disease, Cisanello Hospital, Pisa 56124, Italy
Maurizio Degiuli, Rossella Reddavid, University of Turin, Department of Oncology, Surgical Oncology and Digestive Surgery, San Luigi University Hospital, Orbassano 10043, Italy
Author contributions: Fumagalli U and de Pascale S conceived and designed the study; Fumagalli U implemented the study and drafted the article; Celotti A made substantial contributions to the acquisition and analysis of data; Baiocchi GL made substantial contributions to the analysis and interpretation of data; Verlato G reviewed the statistical analysis. All authors substantially contributed to the interpretation of data, made critical revisions related to important intellectual content of the manuscript, and approved the final version of the manuscript.
Institutional review board statement: The publication of this manuscript has been reviewed and approved by the institutional review board of the Department of Clinical and Experimental Sciences of the University of Brescia, Brescia, Italy.
Informed consent statement: Patients were not required to provide informed consent to this study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors have received no funding and declare no conflicts of interest in relation to this specific work.
Data sharing statement: No additional data are available.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Uberto Fumagalli, MD, Director, Surgical Oncologist, Department of Digestive Surgery, IEO European Institute of Oncology IRCCS, Via Ripamonti 435, Milano 20141, Italy. email@example.com
Telephone: +39-2-57489680 Fax: +39-2-57489930
Received: October 22, 2018
Peer-review started: October 22, 2018
First decision: November 29, 2018
Revised: January 4, 2019
Accepted: January 9, 2019
Article in press: January 9, 2019
Published online: January 21, 2019