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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2019; 25(3): 346-355
Published online Jan 21, 2019. doi: 10.3748/wjg.v25.i3.346
Published online Jan 21, 2019. doi: 10.3748/wjg.v25.i3.346
Effects of positive acceleration (+Gz stress) on liver enzymes, energy metabolism, and liver histology in rats
Bin Shi, Hong-Yi Zhang, Department of Hepatobiliary Surgery, Air Force Medical Center, PLA, Beijing 100142, China
Xian-Qiang Wang, Department of Pediatrics, Chinese PLA General Hospital and PLA Medical School, Beijing 100853, China
Wei-Dong Duan, Ying-Wei Pan, Department of Hepatobiliary Surgery, Chinese PLA General Hospital and PLA Medical School, Beijing 100853, China
Guo-Dong Tan, Outpatient Department, Air Command Headquarters, Beijing 100038, China
Han-Jing Gao, Department of Ultrasound, Chinese PLA General Hospital and PLA Medical School, Beijing 100853, China
Qing-Jun Guo, Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Author contributions: Zhang HY and Shi B designed the research; Shi B, Wang XQ, and Duan WD performed the research; Shi B, Tan GD, and Gao HJ contributed new reagents or analytic tools; Shi B, Pan YW, and Guo QJ analyzed the data; Shi B and Zhang HY wrote the paper.
Supported by the China Post-doctoral Science Foundation Project, No. 2018T111151.
Institutional review board statement: This study was reviewed and approved by the Chinese PLA Air Force Medical Center Institutional Review Board.
Institutional animal care and use committee statement: This study was reviewed and approved by the Chinese PLA Air Force Medical CenterInstitutional animal care and use committee.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: This paper was prepared according to the ARRIVE guidelines.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong-Yi Zhang, MD, Professor, Department of Hepatobiliary Surgery, Air Force Medical Center, PLA, No. 30, Fucheng Road, Haidian District, Beijing 100142, China. qhcgzhy@163.com
Telephone: +86-10-66928312 Fax: +86-10-66928312
Received: October 30, 2018
Peer-review started: October 30, 2018
First decision: November 14, 2018
Revised: December 12, 2018
Accepted: December 21, 2018
Article in press: December 21, 2018
Published online: January 21, 2019
Processing time: 83 Days and 20.5 Hours
Peer-review started: October 30, 2018
First decision: November 14, 2018
Revised: December 12, 2018
Accepted: December 21, 2018
Article in press: December 21, 2018
Published online: January 21, 2019
Processing time: 83 Days and 20.5 Hours
Core Tip
Core tip: Some clinical data showed that liver dysfunction was observed in pilots. However, the reason was not clear. We conducted this experimental study to investigate rat liver function changes in response to repeated +Gz exposures, and to observe the portal venous flow volume, liver function indexes, liver tissue malondialdehyde, Na+-K+-ATPase activity, and changes in liver histology. We found that repeated +Gz exposures transiently cause hepatocyte injury and affect liver metabolism and morphological structure.