Prospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2019; 25(28): 3808-3822
Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3808
Comparison of the use of wireless capsule endoscopy with magnetic resonance enterography in children with inflammatory bowel disease
Nadia Mazen Hijaz, Thomas Mario Attard, Jennifer Marie Colombo, Neil Joseph Mardis, Craig Alan Friesen
Nadia Mazen Hijaz, Thomas Mario Attard, Jennifer Marie Colombo, Neil Joseph Mardis, Craig Alan Friesen, Division of Gastroenterology Hepatology and Nutrition, University of Missouri Kansas City, Children’s Mercy Hospital Kansas City, Kansas City, MO 64108, United States
Author contributions: Hijaz NM has designed the research study under the guidance of Attard TM and Colombo JM. Hijaz NM supervised the recruitment, safety and timed performance of every single aspect of study procedures. Hijaz NM has collected, processed, computed and summarized all the data. Attard TM and Colombo JM have participated in the capsule endoscopy reading of the study. Mardis NJ has participated in reading the magnetic resonance imaging of the study. Hijaz NM, Attard TM, Friesen CA analyzed the data statistically. Hijaz NM wrote the paper and then revised with guidance of Attard TA, Colombo JM, Friesen CA and Mardis NJ.
Supported by the donation of wireless Small bowel capsule and patency capsules from Giving imaging, Ltd Medtronic company with the funding agreement from Given investigator-initiated study No. 13-12.
Institutional review board statement: The study was reviewed and approved by the institutional review boards of Children's Mercy Hospital Pediatric Institutional Review Board, IRB #13080263.
Clinical trial registration statement: The clinical trial is registered with, using identifier NCT02182947. Details can be found at
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: All authors of this manuscript have no conflict of interest to disclose.
Data sharing statement: There is no additional data available.
CONSORT 2010 statement: Not applicable.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Nadia Mazen Hijaz, MD, Assistant Professor, Doctor, Division of Gastroenterology Hepatology and Nutrition, University of Missouri Kansas City, Children Mercy Hospital Kansas City, 2401 Gillham Road, Kansas City, MO 64108, United States.
Telephone: +1-816-3023400 Fax: +1-816-3029735
Received: March 22, 2019
Peer-review started: March 22, 2019
First decision: April 16, 2019
Revised: May 4, 2019
Accepted: July 5, 2019
Article in press: July 5, 2019
Published online: July 28, 2019
Core Tip

Core tip: There are a number of prospective adult studies and few in pediatrics comparing magnetic resonance imaging (MRE) to wireless capsule endoscopy (WCE) in identifying small bowel (SB) Crohn’s disease (CD) that showed no significant difference in the diagnostic yield and accuracy of MRE and WCE in established non-stricturing crohns disease or suspected and established CD together. This study is the first prospective study in children with established inflammatory bowel disease in the United States assessing and comparing the roles of MRE and WCE in identifying SB disease involvement in relation to clinical and histological indices.