Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2019; 25(28): 3775-3786
Published online Jul 28, 2019. doi: 10.3748/wjg.v25.i28.3775
MiR-205 mediated APC regulation contributes to pancreatic cancer cell proliferation
Rui-Feng Qin, Jia Zhang, Hao-Ran Huo, Zeng-Jiang Yuan, Jia-Dong Xue
Rui-Feng Qin, Jia Zhang, Hao-Ran Huo, Zeng-Jiang Yuan, Jia-Dong Xue, Third Department of General Surgery, Handan Central Hospital, Handan 056000, Hebei Province, China
Author contributions: Qin RF designed the research; Qin RF, Zhang J, Huo HR, Yuan ZJ, and Xue JD performed the research; Qin RF and Zhang J analyzed the data; Qin RF wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Handan Central Hospital Institutional Review Board.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Rui-Feng Qin, MSc, Associate Chief Physician, Third Department of General Surgery, Handan Central Hospital, No. 15, Zhonghua South Street, Handan 056000, Hebei Province, China.
Telephone: +86-133-8300-0998 Fax: +86-310-2110011
Received: March 27, 2019
Peer-review started: March 27, 2019
First decision: May 16, 2019
Revised: June 7, 2019
Accepted: June 22, 2019
Article in press: June 23, 2019
Published online: July 28, 2019
Core Tip

Core tip: A large number of microRNAs with altered expression were identified in pancreatic cancer. MiR-205 was found to be significantly up-regulated in pancreatic cancer. Adenomatous polyposis coli (APC) was found to be a validated target of miR-205 and down-regulated in pancreatic cancer. Proliferation experiments showed that miR-205 could promote cell proliferation in pancreatic cancer by targeting APC.