Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2019; 25(26): 3380-3391
Published online Jul 14, 2019. doi: 10.3748/wjg.v25.i26.3380
Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil resistance in cholangiocarcinoma cells
Shuang-Shuang Guo, Ying Wang, Qing-Xia Fan
Shuang-Shuang Guo, Qing-Xia Fan, Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Shuang-Shuang Guo, Ying Wang, Department of Oncology, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, Henan Province, China
Author contributions: Guo SS performed the experiments, analyzed the data, and wrote the manuscript; Wang Y analyzed the data; Fan QX designed the experiments and edited the manuscript.
Institutional review board statement: This study was reviewed and approved by the First Affiliated Hospital of Zhengzhou University.
Conflict-of-interest statement: All authors have nothing to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qing-Xia Fan, MD, PhD, Doctor, Department of Oncology, the First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. huinaochangtu81@163.com
Telephone: +86-371-66265533 Fax: +86-371-66265533
Received: April 12, 2019
Peer-review started: April 12, 2019
First decision: May 9, 2019
Revised: May 18, 2019
Accepted: May 31, 2019
Article in press: June 1, 2019
Published online: July 14, 2019
Processing time: 93 Days and 7.4 Hours
Core Tip

Core tip: We report that raddeanin A (RA) reduced cell viability, migration, and colony formation abilities in cholangiocarcinoma cells and enhanced the antitumor effect of 5-Fu in cholangiocarcinoma cells. This study also demonstrated that the anticancer effects of RA were associated with apoptosis-related proteins Bax and B cell lymphoma 2 as well as cell cycle-related proteins Wee1, cyclin D1, cyclin E, and cyclooxygenase-2.