Systematic Reviews
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2019; 25(23): 2947-2960
Published online Jun 21, 2019. doi: 10.3748/wjg.v25.i23.2947
Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review
Pamela A Norton, Anand S Mehta
Pamela A Norton, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102, United States
Anand S Mehta, Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC 29425, United States
Author contributions: Norton PA and Mehta AS designed the research; Norton PA performed the searches; Norton PA and Mehta AS analyzed the data and wrote the paper.
Conflict-of-interest statement: The authors declare no conflicts.
PRISMA 2009 Checklist statement: This systematic review was conducted according to the PRISMA 2009 Checklist (
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Pamela A Norton, PhD, Associate Professor, Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, United States.
Telephone: +1-215-762-4146
Received: March 14, 2019
Peer-review started: March 14, 2019
First decision: April 11, 2019
Revised: April 25, 2019
Accepted: May 18, 2019
Article in press: May 18, 2019
Published online: June 21, 2019
Core Tip

Core tip: The increased level of core fucosylated N-linked glycoproteins detected in some patients with hepatocellular carcinoma may occur via several potential molecular mechanisms. We report that the genes GMDS and TSTA3, which are associated with the de novo synthesis of the fucose donor species, guanosine diphosphate fucose, can be amplified in some hepatocellular carcinoma patients. Amplification seems to be the most common genetic alteration affecting the genes that control the production of core fucosylated proteins.