Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2019; 25(23): 2924-2934
Published online Jun 21, 2019. doi: 10.3748/wjg.v25.i23.2924
Effects of Bifidobacterium infantis on cytokine-induced neutrophil chemoattractant and insulin-like growth factor-1 in the ileum of rats with endotoxin injury
Wei Wang, Mei Sun, Yu-Ling Zheng, Liu-Yu Sun, Shu-Qiang Qu
Wei Wang, Yu-Ling Zheng, Liu-Yu Sun, Shu-Qiang Qu, Department of Pediatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Mei Sun, Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wang W and Sun M designed the experiment; all authors took part in this experiment; Zheng Y collected the data; Sun L performed analysis of the data; all authors participated in writing and critical revision of the manuscript; Qu S provided final approval of the manuscript.
Supported by the Education Department of Heilongjiang Province, China, No. 11521124.
Institutional review board statement: This study was approved by the Institutional Review Board of the Second Affiliated Hospital of Harbin Medical University.
Institutional animal care and use committee statement: This study was approved by the Institutional Animal Ethical Review Board of the Second Affiliated Hospital of Harbin Medical University (SYDW2018-115).
Conflict-of-interest statement: No conflict of interest exists.
Data sharing statement: No additional data sharing.
ARRIVE guidelines statement: The ARRIVE Guidelines have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shu-Qiang Qu, PhD, Chief Doctor, Director, Professor, Teacher, Pediatrician, Department of Pediatrics, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin 150086, Heilongjiang Province, China. qushuqiang1962@hotmail.com
Telephone: +86-451-86297730 Fax: +86-451-86297730
Received: November 21, 2018
Peer-review started: November 22, 2018
First decision: December 12, 2018
Revised: March 12, 2019
Accepted: March 29, 2019
Article in press: March 30, 2019
Published online: June 21, 2019
Core Tip

Core tip: The purpose of this article is to investigate the effects of Bifidobacterium on cytokine-induced neutrophil chemoattractant and insulin-like growth factor 1 (IGF-1) in the ileum of rats with endotoxin injury. It was found that Bifidobacterium may increase IGF-1 expression and enhance intestinal immune barrier function in rats with endotoxin injury.