Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2019; 25(23): 2898-2910
Published online Jun 21, 2019. doi: 10.3748/wjg.v25.i23.2898
NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling
Wei-Dong Fan, Tao Chen, Peng-Jun Liu
Wei-Dong Fan, Department of Gastroenterology, the Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang 215600, Jiangsu Province, China
Tao Chen, Peng-Jun Liu, Department of Gastroenterology, the Wujin Hospital Affiliated to Jiangsu University, Changzhou 213002, Jiangsu Province, China
Author contributions: Fan WD and Liu PJ designed the research; Fan WD and Chen T performed the research; Fan WD and Chen T analyzed the data; Liu PJ wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Wujin Hospital Affiliated to Jiangsu University.
Conflict-of-interest statement: The authors declare no financial and personal relationships with other people or organizations.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Peng-Jun Liu, MD, Attending Doctor, Chief Doctor, Department of Gastroenterology, the Wujin Hospital Affiliated to Jiangsu University, No. 2, Yongning North Road, Changzhou 213002, Jiangsu Province, China.
Telephone: +86-519-5336190 Fax: +86-519-5336190
Received: April 4, 2019
Peer-review started: April 4, 2019
First decision: April 11, 2019
Revised: April 27, 2019
Accepted: May 18, 2019
Article in press: May 18, 2019
Published online: June 21, 2019
Core Tip

Core tip: Expression of NIMA related kinase 2 (NEK2) is significantly up-regulated in human gastric cancer (GC) tissues and cells. Combined NEK2 and ERK expression may predict overall survival in patients with GC. NEK2 regulates the expression of cyclin D1 by affecting the phosphorylation of ERK and c-JUN in GC and mediates cell proliferation via the ERK/c-JUN/cyclin D1 axis.