Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2019; 25(23): 2878-2886
Published online Jun 21, 2019. doi: 10.3748/wjg.v25.i23.2878
Published online Jun 21, 2019. doi: 10.3748/wjg.v25.i23.2878
The role of endoscopy in the management of hereditary diffuse gastric cancer syndrome
Shria Kumar, Gregory G Ginsberg, Bryson W Katona, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States
Jessica M Long, Division of Hematology and Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States
Author contributions: Kumar S and Katona BW planned the minireview format, reviewed literature, and wrote the paper; Long JM and Ginsberg GG provided expertise in genetics and endoscopy, respectively, and contributed via editing and writing
Supported by the National Institutes of Health T32 grant (Kumar S ; Grant NO: 5T32DK7740-22) .
Conflict-of-interest statement: Dr. Katona reports personal fees from Exact Sciences, other from Janssen, other from Immunovia, outside the submitted work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bryson W Katona, MD, PhD, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd., 751 South Pavilion, Philadelphia, PA 19104, United States. bryson.katona@uphs.upenn.edu
Telephone: +1-215-349-8222 Fax: +1-215-349-5915
Received: March 17, 2019
Peer-review started: March 19, 2019
First decision: April 4, 2019
Revised: April 8, 2019
Accepted: April 29, 2019
Article in press: April 29, 2019
Published online: June 21, 2019
Peer-review started: March 19, 2019
First decision: April 4, 2019
Revised: April 8, 2019
Accepted: April 29, 2019
Article in press: April 29, 2019
Published online: June 21, 2019
Core Tip
Core tip: Individuals with hereditary diffuse gastric cancer (HDGC) syndrome are at increased risk of diffuse gastric cancer, and are often recommended to undergo prophylactic total gastrectomy, especially in the presence of a pathogenic germline CDH1 variant. Endoscopy is important in the initial management and surveillance of individuals with HDGC syndrome, yet sensitivity of endoscopy for detection of cancer foci in this population is poor. Alternative endoscopic modalities have not been found to be helpful. Ultimately, there is much to be learned about how to best use endoscopy in management of HDGC.